| pubmed-article:7939411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7939411 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7939411 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:7939411 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:7939411 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:7939411 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:7939411 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7939411 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7939411 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7939411 | pubmed:dateCreated | 1994-10-24 | lld:pubmed |
| pubmed-article:7939411 | pubmed:abstractText | In the present study we investigated the influence of the PKC-inhibitor GF109203X on cytokine- and endotoxin-induced expression of intercellular adhesion molecule 1 (ICAM-1) and on the adhesion of lymphocytes to cytokine-activated endothelial cells. We found that tumour necrosis factor alpha (TNF-alpha)- and lipopolysaccharide (LPS)-induced ICAM-1 expression on a human endothelium-derived cell line (EA.hy926) were unaffected by the PKC-inhibitor and thus appeared to be independent of PKC activation. In contrast, GF109203X significantly reduced ICAM-1 expression induced by interferon-gamma (IFN-gamma) and interleukin-1 (IL-1). The functional relevance of these findings was evaluated in an adhesion assay using human umbilical vein endothelial cells (HUVEC) and peripheral blood mononuclear cells (PBMC). In fact, the IFN-gamma- and IL-1-induced adhesion of PBMC to cytokine treated HUVEC could be down-regulated by the PKC-inhibitor, whereas TNF alpha- and LPS-mediated adhesion was not affected. Additionally, the IL-1-driven ICAM-1 expression on HUVEC as well as the IL-1 induced adhesion of PBMC to HUVEC was found to be TNF-dependent, as both effects could be inhibited by an anti-TNF-alpha monoclonal antibody (MoAb) (MAK195). Based on these data on differential regulation of cytokine-induced lymphocyte-endothelium interactions our study supports the use of PKC-inhibitors as additive modulators in cytokine related pathophysiological conditions. | lld:pubmed |
| pubmed-article:7939411 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7939411 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7939411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7939411 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7939411 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:7939411 | pubmed:author | pubmed-author:HollerEE | lld:pubmed |
| pubmed-article:7939411 | pubmed:author | pubmed-author:BornkammG WGW | lld:pubmed |
| pubmed-article:7939411 | pubmed:author | pubmed-author:EissnerGG | lld:pubmed |
| pubmed-article:7939411 | pubmed:author | pubmed-author:KölchWW | lld:pubmed |
| pubmed-article:7939411 | pubmed:author | pubmed-author:MischakHH | lld:pubmed |
| pubmed-article:7939411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7939411 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:7939411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7939411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7939411 | pubmed:pagination | 395-402 | lld:pubmed |
| pubmed-article:7939411 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
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| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
| pubmed-article:7939411 | pubmed:meshHeading | pubmed-meshheading:7939411-... | lld:pubmed |
| pubmed-article:7939411 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7939411 | pubmed:articleTitle | Differential role of protein kinase C in cytokine induced lymphocyte-endothelium interaction in vitro. | lld:pubmed |
| pubmed-article:7939411 | pubmed:affiliation | GSF-Institut für Klinische Molekularbiologie, München, Germany. | lld:pubmed |
| pubmed-article:7939411 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7939411 | lld:pubmed |
