| pubmed-article:7937827 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7937827 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7937827 | lifeskim:mentions | umls-concept:C0282114 | lld:lifeskim |
| pubmed-article:7937827 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:7937827 | lifeskim:mentions | umls-concept:C0042874 | lld:lifeskim |
| pubmed-article:7937827 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:7937827 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:7937827 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:7937827 | pubmed:dateCreated | 1994-11-10 | lld:pubmed |
| pubmed-article:7937827 | pubmed:abstractText | A kinetic model of vitamin E transport in humans is described using data from our studies with deuterium-labeled stereoisomers of alpha-tocopherol (RRR- and SRR-). In normal subjects, both alpha-tocopherols are present at similar concentrations in chylomicrons, but by 24 hr, RRR-alpha-tocopherol is at higher plasma concentrations because RRR-alpha-tocopherol is preferentially incorporated into very low density lipoproteins, which are then secreted into plasma. In three nondiscriminator patients with familial isolated vitamin E deficiency, the fractional disappearance rates (mean +/- SD) of deuterium-labeled RRR- and SRR-alpha-tocopherols in plasma were 1.4 +/- 0.6 and 1.3 +/- 0.3 pools per day, respectively (difference, 0.1 +/- 0.3). In these patients, plasma concentrations of both RRR- and SRR-alpha-tocopherols decreased similarly to SRR-alpha-tocopherol in controls. In six controls, fractional disappearance rates of deuterium-labeled RRR-alpha-tocopherol (0.4 +/- 0.1 pool per day) were significantly (P < 0.01) slower than for SRR- (1.2 +/- 0.6). The differences (0.8 +/- 0.6 pool per day) between these two rates in controls estimate the rate at which RRR-alpha-tocopherol, which had left the plasma, was returned to the plasma. Although plasma labeled RRR-alpha-tocopherol concentrations in controls appear to change slowly, these data show that both RRR- and SRR-alpha-tocopherols leave the plasma rapidly, but only RRR-alpha-tocopherol is returned to the plasma, likely in nascent very low density lipoproteins. This recycling of RRR-alpha-tocopherol accounts for nearly 1 pool of alpha-tocopherol per day. | lld:pubmed |
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| pubmed-article:7937827 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7937827 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7937827 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7937827 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7937827 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7937827 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7937827 | pubmed:author | pubmed-author:KaydenH JHJ | lld:pubmed |
| pubmed-article:7937827 | pubmed:author | pubmed-author:RamakrishnanR... | lld:pubmed |
| pubmed-article:7937827 | pubmed:author | pubmed-author:TraberM GMG | lld:pubmed |
| pubmed-article:7937827 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7937827 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:7937827 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:7937827 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7937827 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7937827 | pubmed:pagination | 10005-8 | lld:pubmed |
| pubmed-article:7937827 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7937827 | pubmed:meshHeading | pubmed-meshheading:7937827-... | lld:pubmed |
| pubmed-article:7937827 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7937827 | pubmed:articleTitle | Human plasma vitamin E kinetics demonstrate rapid recycling of plasma RRR-alpha-tocopherol. | lld:pubmed |
| pubmed-article:7937827 | pubmed:affiliation | Department of Medicine, New York University School of Medicine, NY 10016. | lld:pubmed |
| pubmed-article:7937827 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7937827 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7937827 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7937827 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
| pubmed-article:7937827 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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