| pubmed-article:7937560 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7937560 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:7937560 | lifeskim:mentions | umls-concept:C0599840 | lld:lifeskim |
| pubmed-article:7937560 | lifeskim:mentions | umls-concept:C0003374 | lld:lifeskim |
| pubmed-article:7937560 | lifeskim:mentions | umls-concept:C0280606 | lld:lifeskim |
| pubmed-article:7937560 | lifeskim:mentions | umls-concept:C0289702 | lld:lifeskim |
| pubmed-article:7937560 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7937560 | pubmed:dateCreated | 1994-11-15 | lld:pubmed |
| pubmed-article:7937560 | pubmed:abstractText | Microbial metabolism studies of the semisynthetic antimalarial anhydrodihydroartemisinin (1), have shown that it is metabolized by a number of microorganisms. Large scale fermentation with Streptomyces lavendulae L-105 and Rhizopogon species (ATCC 36060) have resulted in the isolation of four microbial metabolites. These metabolites have been identified as a 14-carbon rearranged product (2), 9 beta-hydroxyanhydrodihydroartemisinin (3), 11-epi-deoxydihydroartemisinin (4), and 3 alpha-hydroxydeoxyanhydrodihydroartemisinin (5). Microbial metabolites were completely characterized by spectral methods, including 1H-NMR and 13C-NMR spectroscopy. The structure and stereochemistry of metabolite 2 were unequivocally established by X-ray crystallographic analysis. Thermospray mass spectroscopy/high-performance liquid chromatographic analyses of plasma from rats used in mammalian metabolism studies of 1 have shown microbial metabolite 3 to be the major mammalian metabolite. In vitro antimalarial testing has shown metabolite 3 to possess antimalarial activity. | lld:pubmed |
| pubmed-article:7937560 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7937560 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7937560 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7937560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7937560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7937560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7937560 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7937560 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7937560 | pubmed:issn | 0724-8741 | lld:pubmed |
| pubmed-article:7937560 | pubmed:author | pubmed-author:BakerJ KJK | lld:pubmed |
| pubmed-article:7937560 | pubmed:author | pubmed-author:HuffordC DCD | lld:pubmed |
| pubmed-article:7937560 | pubmed:author | pubmed-author:el-FeralyF... | lld:pubmed |
| pubmed-article:7937560 | pubmed:author | pubmed-author:RogersR DRD | lld:pubmed |
| pubmed-article:7937560 | pubmed:author | pubmed-author:KhalifaS ISI | lld:pubmed |
| pubmed-article:7937560 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7937560 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:7937560 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7937560 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7937560 | pubmed:pagination | 990-4 | lld:pubmed |
| pubmed-article:7937560 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:meshHeading | pubmed-meshheading:7937560-... | lld:pubmed |
| pubmed-article:7937560 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7937560 | pubmed:articleTitle | Microbial and mammalian metabolism studies of the semisynthetic antimalarial, anhydrodihydroartemisinin. | lld:pubmed |
| pubmed-article:7937560 | pubmed:affiliation | Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677. | lld:pubmed |
| pubmed-article:7937560 | pubmed:publicationType | Journal Article | lld:pubmed |
