| pubmed-article:7931063 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7931063 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7931063 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:7931063 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:7931063 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7931063 | pubmed:dateCreated | 1994-11-2 | lld:pubmed |
| pubmed-article:7931063 | pubmed:abstractText | The primary roles of T cells and B cells in the initiation of systemic autoimmunity are unclear. To investigate the role of B cells, we crossed the "Jh knockout" mutation onto the autoimmune lpr/lpr background. Animals homozygous for both traits were obtained. As expected, these animals lack B cells. These animals also show no signs of autoimmune kidney destruction nor vasculitis, in spite of carrying the lpr/lpr mutation. In contrast, lpr/lpr littermates that had B cells had severe nephritis and vasculitis, as well as autoantibodies. These results demonstrate a primary role for B cells and/or (auto)antibodies in initiating several types of autoimmune-mediated tissue destruction. The implications of this finding for models and therapy of autoimmunity are discussed. | lld:pubmed |
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| pubmed-article:7931063 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7931063 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7931063 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7931063 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7931063 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:7931063 | pubmed:author | pubmed-author:MadaioM PMP | lld:pubmed |
| pubmed-article:7931063 | pubmed:author | pubmed-author:NgFF | lld:pubmed |
| pubmed-article:7931063 | pubmed:author | pubmed-author:HuszarDD | lld:pubmed |
| pubmed-article:7931063 | pubmed:author | pubmed-author:ShlomchikM... | lld:pubmed |
| pubmed-article:7931063 | pubmed:author | pubmed-author:TrounsteinMM | lld:pubmed |
| pubmed-article:7931063 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7931063 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7931063 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:7931063 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7931063 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7931063 | pubmed:pagination | 1295-306 | lld:pubmed |
| pubmed-article:7931063 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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