| pubmed-article:7923910 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7923910 | lifeskim:mentions | umls-concept:C0035435 | lld:lifeskim |
| pubmed-article:7923910 | lifeskim:mentions | umls-concept:C2246374 | lld:lifeskim |
| pubmed-article:7923910 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:7923910 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:7923910 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7923910 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:7923910 | lifeskim:mentions | umls-concept:C0289104 | lld:lifeskim |
| pubmed-article:7923910 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7923910 | pubmed:dateCreated | 1994-10-28 | lld:pubmed |
| pubmed-article:7923910 | pubmed:abstractText | The Su autoantigen was characterized biochemically using human and murine autoimmune sera and the clinical significance of anti-Su antibodies was studied in 236 Japanese and 160 American patients with systemic rheumatic diseases. Anti-Su in immunodiffusion (ID) was strongly associated with immunoprecipitation of one or more 100- to 102-kDa proteins by MRL/lpr mouse sera (27/32 of ID positive vs 4/20 of ID negative, P = 0.000016), and all four human anti-Su reference sera immunoprecipitated the 100/102-kDa protein(s). In addition, all sera immunoprecipitated a less efficiently labeled approximately 200-kDa protein that comigrated on sucrose density gradients with the 100/102-kDa proteins. Based on these data, a complex of the 100/102-kDa and 200-kDa proteins is likely to be the main target of anti-Su antibodies. Three of four anti-Su monospecific sera were negative for immunofluorescent antinuclear antibodies (ANA), suggesting anti-Su antibodies may be associated with a negative ANA in some cases. Autoantibodies to Su were detected frequently by immunoprecipitation in systemic lupus erythematosus (17-21%), scleroderma (13-20%), and overlap syndrome (22-40%) and were associated with autoantibodies to Ku. | lld:pubmed |
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| pubmed-article:7923910 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7923910 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7923910 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7923910 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7923910 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7923910 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:OgasawaraTT | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:CohenP LPL | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:SatohMM | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:ChouC HCH | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:EisenbergR... | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:McCauliffeD... | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:SuwaAA | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:HirakataMM | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:TreadwellE... | lld:pubmed |
| pubmed-article:7923910 | pubmed:author | pubmed-author:LangdonJ JJJ | lld:pubmed |
| pubmed-article:7923910 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7923910 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:7923910 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7923910 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7923910 | pubmed:pagination | 132-41 | lld:pubmed |
| pubmed-article:7923910 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7923910 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7923910 | pubmed:articleTitle | Characterization of the Su antigen, a macromolecular complex of 100/102 and 200-kDa proteins recognized by autoantibodies in systemic rheumatic diseases. | lld:pubmed |
| pubmed-article:7923910 | pubmed:affiliation | Department of Medicine, Thurston Arthritis Research Center, Chapel Hill, North Carolina. | lld:pubmed |
| pubmed-article:7923910 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7923910 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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