| pubmed-article:7923631 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C2339371 | lld:lifeskim |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C0006776 | lld:lifeskim |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:7923631 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:7923631 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7923631 | pubmed:dateCreated | 1994-11-21 | lld:pubmed |
| pubmed-article:7923631 | pubmed:abstractText | The intracellular mechanism underlying the Ca(2+)-induced enhancement of the L-type Ca2+ current (ICa) was examined in adult rabbit cardiac ventricular myocytes by using patch-clamp methodology. Internal Ca2+ was elevated by flash photolysis of the Ca2+ chelator Nitr 5, and intracellular Ca2+ levels were simultaneously monitored by Fluo 3 fluorescence. Flash photolysis of Nitr 5 produced a rapid (< 1-second) elevation of internal Ca2+, which led to enhancement (39% to 51% above control) of the peak inward Ca2+ current after a delay of 20 to 120 seconds. Internal dialysis of myocytes with synthetic inhibitory peptides derived from the pseudosubstrate (peptide 273-302) and calmodulin binding (peptide 291-317) regions within the regulatory domain of multifunctional Ca2+/calmodulin-dependent protein kinase (CaM kinase) blocked enhancement of ICa produced by elevation of internal Ca2+ but not that produced by beta-adrenergic stimulation. These inhibitory peptides also had no effect on the elevation of internal Ca2+ produced by flash photolysis of Nitr 5. A pseudosubstrate inhibitory peptide derived from protein kinase C had no significant effect on Ca(2+)-dependent enhancement of ICa. We conclude that CaM kinase mediates the Ca(2+)-induced enhancement of ICa in mammalian cardiac myocytes by a mechanism likely involving direct phosphorylation of the L-type Ca2+ channel complex or an associated regulatory protein. | lld:pubmed |
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| pubmed-article:7923631 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7923631 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7923631 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7923631 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7923631 | pubmed:issn | 0009-7330 | lld:pubmed |
| pubmed-article:7923631 | pubmed:author | pubmed-author:SchulmanHH | lld:pubmed |
| pubmed-article:7923631 | pubmed:author | pubmed-author:AndersonM EME | lld:pubmed |
| pubmed-article:7923631 | pubmed:author | pubmed-author:PremackB ABA | lld:pubmed |
| pubmed-article:7923631 | pubmed:author | pubmed-author:BraunA PAP | lld:pubmed |
| pubmed-article:7923631 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7923631 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:7923631 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7923631 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7923631 | pubmed:pagination | 854-61 | lld:pubmed |
| pubmed-article:7923631 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7923631 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7923631 | pubmed:articleTitle | Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes. | lld:pubmed |
| pubmed-article:7923631 | pubmed:affiliation | Falk Cardiovascular Research Center, Department of Medicine, Stanford University School of Medicine 94305-5401. | lld:pubmed |
| pubmed-article:7923631 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7923631 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7923631 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7923631 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7923631 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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