| pubmed-article:7919177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7919177 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7919177 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:7919177 | lifeskim:mentions | umls-concept:C1153410 | lld:lifeskim |
| pubmed-article:7919177 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:7919177 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7919177 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:7919177 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7919177 | pubmed:dateCreated | 1994-11-10 | lld:pubmed |
| pubmed-article:7919177 | pubmed:abstractText | The potassium channel blocker, 4-aminopyridine (4-AP), stimulates neurotransmitter release via plasma membrane depolarization and subsequent activation of voltage-gated calcium channels. The present study assessed the effects of 4-AP on intracellular calcium levels in the human neuroblastoma cell line CHP-100. Blockade of K+ channels with 4-AP significantly increased intracellular calcium concentration ([Ca2+]i). This increase occurred via activation of plasma membrane Ca2+ channels. The 4-AP induced rise in [Ca2+]i was not inhibited by the L-type Ca2+ channel blocker nifedipine but was sensitive to the N-type Ca2+ channel blocker omega-contotoxin GVIA. Tetrodotoxin did not alter the effect of 4-AP. These results suggest that in CHP-100 cells, following inhibition of K+ channels by 4-AP, N-type Ca2+ channels are activated. | lld:pubmed |
| pubmed-article:7919177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7919177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7919177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7919177 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7919177 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:7919177 | pubmed:author | pubmed-author:BrammerMM | lld:pubmed |
| pubmed-article:7919177 | pubmed:author | pubmed-author:MangelA WAW | lld:pubmed |
| pubmed-article:7919177 | pubmed:author | pubmed-author:LarrCC | lld:pubmed |
| pubmed-article:7919177 | pubmed:author | pubmed-author:CampbellII | lld:pubmed |
| pubmed-article:7919177 | pubmed:author | pubmed-author:BasavappaSS | lld:pubmed |
| pubmed-article:7919177 | pubmed:author | pubmed-author:Romano-SilvaM... | lld:pubmed |
| pubmed-article:7919177 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7919177 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:7919177 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:7919177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7919177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7919177 | pubmed:pagination | 1256-8 | lld:pubmed |
| pubmed-article:7919177 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:meshHeading | pubmed-meshheading:7919177-... | lld:pubmed |
| pubmed-article:7919177 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7919177 | pubmed:articleTitle | Inhibition of K+ channel activity by 4-AP stimulates N-type Ca2+ channels in CHP-100 cells. | lld:pubmed |
| pubmed-article:7919177 | pubmed:affiliation | Duke University Medical Center, Division of Gastroenterology, Durham, North Carolina 27710. | lld:pubmed |
| pubmed-article:7919177 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7919177 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
