| pubmed-article:7917778 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7917778 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:7917778 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:7917778 | lifeskim:mentions | umls-concept:C0019932 | lld:lifeskim |
| pubmed-article:7917778 | lifeskim:mentions | umls-concept:C0025329 | lld:lifeskim |
| pubmed-article:7917778 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7917778 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7917778 | pubmed:dateCreated | 1994-11-10 | lld:pubmed |
| pubmed-article:7917778 | pubmed:abstractText | 1. Up to 40% of female asthmatic subjects suffer a premenstrual deterioration in their condition which may be ameliorated by progesterone supplementation, although the mechanism responsible for this phenomenon is not understood. In vitro studies have shown that female sex-steroid hormones potentiate the bronchorelaxant effect of isoprenaline, whilst in vivo it has been shown that females exhibit greater sensitivity of systemic beta 2-adrenoceptor responses. 2. The aim of the present study was to determine whether cyclical alterations in beta 2-adrenoceptor expression, occurring under the influence of ovarian sex-steroid hormones, may offer an explanation for these findings. In vitro parameters of lymphocyte beta 2-adrenoceptor function were investigated in nine normal female subjects (aged 24 +/- 2 years) during the follicular (day 2-4) and luteal (day 21-23) phases of their menstrual cycle, and results were compared with those of nine age-matched healthy male controls studied at the same time intervals. 3. In female subjects there were significant increases in serum concentrations of oestradiol (3.3-fold) and progesterone (10.6-fold) between the follicular and luteal phases of the menstrual cycle, whereas no changes occurred in males. 4. In females during the luteal phase, the increase in sex-steroid hormones was mirrored by an increase in lymphocyte beta 2-adrenoceptor density (Bmax) and in maximal cyclic AMP response to isoprenaline (Emax), which were significantly higher than in male subjects. Mean differences (95% CI) between male and female subjects on visit 2 were 1.09 (0.49 to 1.69) fmol/10(6) cells (P = 0.001) for Bmax, and 3.42 (0.80 to 6.04) pmol/10(6) cells (P = 0.02) for Emax.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:7917778 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7917778 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7917778 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7917778 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7917778 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7917778 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:7917778 | pubmed:author | pubmed-author:McDevittD GDG | lld:pubmed |
| pubmed-article:7917778 | pubmed:author | pubmed-author:PetersJ AJA | lld:pubmed |
| pubmed-article:7917778 | pubmed:author | pubmed-author:WheeldonN MNM | lld:pubmed |
| pubmed-article:7917778 | pubmed:author | pubmed-author:CoutieW JWJ | lld:pubmed |
| pubmed-article:7917778 | pubmed:author | pubmed-author:LipworthB JBJ | lld:pubmed |
| pubmed-article:7917778 | pubmed:author | pubmed-author:NewnhamD MDM | lld:pubmed |
| pubmed-article:7917778 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7917778 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:7917778 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7917778 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7917778 | pubmed:pagination | 583-8 | lld:pubmed |
| pubmed-article:7917778 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7917778 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7917778 | pubmed:articleTitle | Influence of sex-steroid hormones on the regulation of lymphocyte beta 2-adrenoceptors during the menstrual cycle. | lld:pubmed |
| pubmed-article:7917778 | pubmed:affiliation | Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland. | lld:pubmed |
| pubmed-article:7917778 | pubmed:publicationType | Journal Article | lld:pubmed |
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