| pubmed-article:7917503 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C0001047 | lld:lifeskim |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C0028160 | lld:lifeskim |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C0022100 | lld:lifeskim |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:7917503 | lifeskim:mentions | umls-concept:C0439828 | lld:lifeskim |
| pubmed-article:7917503 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7917503 | pubmed:dateCreated | 1994-11-9 | lld:pubmed |
| pubmed-article:7917503 | pubmed:abstractText | 1. In previous studies a rat inhalation model was developed to investigate the efficacy of treatment in acute NO2 intoxication. 2. N-acetylcysteine (NAC) was administered intravenously to study its effect on biochemical variables in broncho-alveolar lavage fluid in acute NO2 intoxicated rats. It was decided to start the intravenous administration of NAC 24 h before the exposure to NO2 to induce higher intracellular glutathione (GSH) levels in lung cells of NAC-treated rats compared to not NAC-treated rats. Because, on theoretical grounds, the therapeutic effect of NAC may be expected to be especially marked during the first 24 h after exposure, the rats were observed for a period of 24 h and were then killed for investigation. A loading dose of 85 mg kg-1 h-1 or 170 mg kg-1 h-1 was followed by a continuous infusion (until autopsy) with a dose of 225 mg kg-1 24 h-1 or 450 mg kg-1 24 h-1 respectively. 3. Twenty four hours after exposure to 175 ppm NO2 (1 ppm is 1.88 mg m-3) for 10 min, NAC did not reduce the increase of variables in broncho-alveolar lavage fluid which reflect the severity of lung damage. 4. The protein and albumin concentration and the activities of angiotensin converting enzyme and alkaline phosphatase in broncho-alveolar lavage fluid after NO2 exposure were even more increased in the NAC-treated than in the saline-treated rats, but none of the differences was statistically significant. 5. In sham exposed rats no effect of NAC was observed. | lld:pubmed |
| pubmed-article:7917503 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7917503 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7917503 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7917503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7917503 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7917503 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7917503 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7917503 | pubmed:issn | 0960-3271 | lld:pubmed |
| pubmed-article:7917503 | pubmed:author | pubmed-author:SangsterBB | lld:pubmed |
| pubmed-article:7917503 | pubmed:author | pubmed-author:DormansJ AJA | lld:pubmed |
| pubmed-article:7917503 | pubmed:author | pubmed-author:van BreeLL | lld:pubmed |
| pubmed-article:7917503 | pubmed:author | pubmed-author:MeulenbeltJJ | lld:pubmed |
| pubmed-article:7917503 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7917503 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:7917503 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7917503 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7917503 | pubmed:pagination | 472-7 | lld:pubmed |
| pubmed-article:7917503 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:meshHeading | pubmed-meshheading:7917503-... | lld:pubmed |
| pubmed-article:7917503 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7917503 | pubmed:articleTitle | No beneficial effect of N-acetylcysteine treatment on broncho-alveolar lavage fluid variables in acute nitrogen dioxide intoxicated rats. | lld:pubmed |
| pubmed-article:7917503 | pubmed:affiliation | National Poison Control Centre, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands. | lld:pubmed |
| pubmed-article:7917503 | pubmed:publicationType | Journal Article | lld:pubmed |
