| pubmed-article:7916011 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C0125575 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C0814810 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C1707719 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7916011 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7916011 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:7916011 | pubmed:dateCreated | 1994-10-12 | lld:pubmed |
| pubmed-article:7916011 | pubmed:abstractText | Phase variation of type 1 fimbriation in Escherichia coli is associated with the site-specific recombination of a 314-bp DNA invertible element. The fim switch directs transcription of fimA, the major fimbrial subunit gene, in one orientation (on) but not the other (off). Switching requires either fimB (on-to-off or off-to-on inversion) or fimE (on-to-off inversion only) and is reduced sharply in strains containing lrp::Tn10 mutations. Both fimE-promoted switching and fimB-promoted switching are stimulated by the amino acids alanine, isoleucine, leucine, and valine, and this regulation requires lrp. Here it is shown that the leucine-responsive regulatory protein (Lrp) binds in and adjacent to the fim switch. Mutations in fim that lower Lrp binding in vitro have corresponding effects on both fimB-promoted switching and fimE-promoted switching in vivo. Lrp initiates binding at one of two sites within the fim switch. Additional cooperative binding results in an extensive region of protection from both DNase I and 1,10-phenanthroline-copper complex-activated DNA cleavage. The region of protection can extend to within 12 bp of the right inverted repeat (switch off) and occupies over one-third of the switch. It is proposed that wrapping of fim DNA around an Lrp complex is required to form a recombination-proficient structure. | lld:pubmed |
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| pubmed-article:7916011 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7916011 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7916011 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7916011 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7916011 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:7916011 | pubmed:author | pubmed-author:BlomfieldI... | lld:pubmed |
| pubmed-article:7916011 | pubmed:author | pubmed-author:GallyD LDL | lld:pubmed |
| pubmed-article:7916011 | pubmed:author | pubmed-author:RuckerT JTJ | lld:pubmed |
| pubmed-article:7916011 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7916011 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:7916011 | pubmed:geneSymbol | fimA | lld:pubmed |
| pubmed-article:7916011 | pubmed:geneSymbol | lrp | lld:pubmed |
| pubmed-article:7916011 | pubmed:geneSymbol | fimB | lld:pubmed |
| pubmed-article:7916011 | pubmed:geneSymbol | fimE | lld:pubmed |
| pubmed-article:7916011 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7916011 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7916011 | pubmed:pagination | 5665-72 | lld:pubmed |
| pubmed-article:7916011 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7916011 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7916011 | pubmed:articleTitle | The leucine-responsive regulatory protein binds to the fim switch to control phase variation of type 1 fimbrial expression in Escherichia coli K-12. | lld:pubmed |
| pubmed-article:7916011 | pubmed:affiliation | Department of Microbiology and Immunology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27157-1064. | lld:pubmed |
| pubmed-article:7916011 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7916011 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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