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pubmed-article:7911556pubmed:abstractTextRelatively few genes in the yeast Saccharomyces cerevisiae are known to contain intervening sequences. As a group, yeast ribosomal protein genes exhibit a higher prevalence of introns when compared to non-ribosomal protein genes. In an effort to quantify this bias we have estimated the prevalence of intron sequences among non-ribosomal protein genes by assessing the number of prp2-sensitive mRNAs in an in vitro translation assay. These results, combined with an updated survey of the GenBank DNA database, support an estimate of 2.5% for intron-containing non-ribosomal protein genes. Furthermore, our observations reveal an intriguing distinction between the distributions of ribosomal protein and non-ribosomal protein intron lengths, suggestive of distinct, gene class-specific evolutionary pressures.lld:pubmed
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pubmed-article:7911556pubmed:articleTitlePrevalence and distribution of introns in non-ribosomal protein genes of yeast.lld:pubmed
pubmed-article:7911556pubmed:affiliationDepartment of Biochemistry, University of Puerto Rico, San Juan 00936-5067.lld:pubmed
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pubmed-article:7911556pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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