| pubmed-article:7904639 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7904639 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:7904639 | lifeskim:mentions | umls-concept:C0012582 | lld:lifeskim |
| pubmed-article:7904639 | lifeskim:mentions | umls-concept:C0044551 | lld:lifeskim |
| pubmed-article:7904639 | lifeskim:mentions | umls-concept:C0039808 | lld:lifeskim |
| pubmed-article:7904639 | lifeskim:mentions | umls-concept:C0006353 | lld:lifeskim |
| pubmed-article:7904639 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7904639 | pubmed:dateCreated | 1994-2-24 | lld:pubmed |
| pubmed-article:7904639 | pubmed:abstractText | The thermodynamics of partitioning (K) of dipyridamole has been determined in n-octanol/buffer and liposome-buffer systems at pH 7.4. Dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC) were used to prepare multilamellar liposomes. Partitioning of dipyridamole did not depend on the amount of n-octanol employed, however, partitioning was dependent upon the quantity of DMPC employed to prepare liposomes. Plots of log K vs 1/T were linear in the n-octanol and liposome systems. Partitioning was generally greater in liposomes than in the n-octanol/buffer system. Among liposomes, the partitioning was greater in DMPC liposomes at all temperatures. The values of enthalpy (delta H) and entropy (delta S) were positive in both the n-octanol and liposome systems. These values were lower in DMPC liposomes and were comparable in the n-octanol and DPPC liposomes. Thus, the interaction of dipyridamole depends on the rigidity of lipid bilayers and liposomes constitute a more selective partitioning system than the n-octanol/buffer system. | lld:pubmed |
| pubmed-article:7904639 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7904639 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7904639 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7904639 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7904639 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7904639 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7904639 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7904639 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7904639 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7904639 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7904639 | pubmed:issn | 0022-3573 | lld:pubmed |
| pubmed-article:7904639 | pubmed:author | pubmed-author:BetageriG VGV | lld:pubmed |
| pubmed-article:7904639 | pubmed:author | pubmed-author:DipaliS RSR | lld:pubmed |
| pubmed-article:7904639 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7904639 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:7904639 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7904639 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7904639 | pubmed:pagination | 931-3 | lld:pubmed |
| pubmed-article:7904639 | pubmed:dateRevised | 2000-12-18 | lld:pubmed |
| pubmed-article:7904639 | pubmed:meshHeading | pubmed-meshheading:7904639-... | lld:pubmed |
| pubmed-article:7904639 | pubmed:meshHeading | pubmed-meshheading:7904639-... | lld:pubmed |
| pubmed-article:7904639 | pubmed:meshHeading | pubmed-meshheading:7904639-... | lld:pubmed |
| pubmed-article:7904639 | pubmed:meshHeading | pubmed-meshheading:7904639-... | lld:pubmed |
| pubmed-article:7904639 | pubmed:meshHeading | pubmed-meshheading:7904639-... | lld:pubmed |
| pubmed-article:7904639 | pubmed:meshHeading | pubmed-meshheading:7904639-... | lld:pubmed |
| pubmed-article:7904639 | pubmed:meshHeading | pubmed-meshheading:7904639-... | lld:pubmed |
| pubmed-article:7904639 | pubmed:meshHeading | pubmed-meshheading:7904639-... | lld:pubmed |
| pubmed-article:7904639 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7904639 | pubmed:articleTitle | Partitioning and thermodynamics of dipyridamole in the n-octanol/buffer and liposome systems. | lld:pubmed |
| pubmed-article:7904639 | pubmed:affiliation | Department of Pharmacal Sciences, School of Pharmacy, Auburn University, AL 36849-5503. | lld:pubmed |
| pubmed-article:7904639 | pubmed:publicationType | Journal Article | lld:pubmed |
