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pubmed-article:7904244pubmed:abstractTextThe activation constants (KA; dose required to occupy 50% of receptors) for reversal of gamma-butyrolactone (GBL)-induced elevation of striatal L-3,4-dihydroxyphenylalanine (L-DOPA) levels via stimulation of presynaptic dopamine receptors were determined for apomorphine and two dopamine D3 receptor-selective agonists, quinpirole and LY163502 (quinelorane). The KA values correlated significantly with the affinities (Ki) of the agonists for the D3 (r = 0.999, P < 0.05) but not the D2 (r = -0.13) receptor, suggesting that striatal synthesis-inhibiting autoreceptors are of the D3 rather than the D2 subtype.lld:pubmed
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pubmed-article:7904244pubmed:articleTitleEvidence that striatal synthesis-inhibiting autoreceptors are dopamine D3 receptors.lld:pubmed
pubmed-article:7904244pubmed:affiliationMillhauser Laboratories, New York University School of Medicine, NY 10016.lld:pubmed
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