| pubmed-article:7904004 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7904004 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
| pubmed-article:7904004 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:7904004 | lifeskim:mentions | umls-concept:C0376387 | lld:lifeskim |
| pubmed-article:7904004 | lifeskim:mentions | umls-concept:C0023911 | lld:lifeskim |
| pubmed-article:7904004 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:7904004 | lifeskim:mentions | umls-concept:C0205262 | lld:lifeskim |
| pubmed-article:7904004 | pubmed:issue | 8890 | lld:pubmed |
| pubmed-article:7904004 | pubmed:dateCreated | 1994-2-10 | lld:pubmed |
| pubmed-article:7904004 | pubmed:abstractText | Hepatitis B virus (HBV) infection almost always recurs after liver transplantation in patients who were surface antigen (HBsAg) positive before surgery but apparent de novo acquisition of infection in a transplant setting has not previously been reported. We have used sensitive techniques to elucidate the origin of such infections in patients in a California transplantation programme. We tested post-transplant serum from 207 patients who had been HBsAg negative and found 20 to be HBsAg positive. The origin of infection was identified in 7 patients, being occult pre-transplant infection in 5 and occult infection in the donor in 2. No pre-transplant patient nor donor with demonstrable HBV DNA had serological markers of hepatitis B. Post-transplant HBV DNA was present in serum from 19 patients. Analysis of the variable pre-S region of HBV demonstrated 100% sequence homology between recipient liver and post-transplant serum (2 patients) and between donor serum and recipient post-transplant serum (2). There was only 84% homology between the 2 different patients infected with subtype adw. 19 patients are alive, 9 without histological evidence of hepatitis (mean follow-up 33 months), and survival was significantly greater than that of a group with recurrent HBV infection. Apparent acquisition of HBV infection with liver transplantation is not rare, and may be due to occult pre-transplant infection or occult infection in the donor. The post-transplant outcome of this infection tends to be benign but our findings do underscore the clinical relevance of HBV infection in the absence of serological markers. | lld:pubmed |
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| pubmed-article:7904004 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7904004 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7904004 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7904004 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7904004 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7904004 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:7904004 | pubmed:author | pubmed-author:KimMM | lld:pubmed |
| pubmed-article:7904004 | pubmed:author | pubmed-author:AscherN LNL | lld:pubmed |
| pubmed-article:7904004 | pubmed:author | pubmed-author:RobertsJ PJP | lld:pubmed |
| pubmed-article:7904004 | pubmed:author | pubmed-author:CareyKK | lld:pubmed |
| pubmed-article:7904004 | pubmed:author | pubmed-author:WrightT LTL | lld:pubmed |
| pubmed-article:7904004 | pubmed:author | pubmed-author:FerrellLL | lld:pubmed |
| pubmed-article:7904004 | pubmed:author | pubmed-author:MamishDD | lld:pubmed |
| pubmed-article:7904004 | pubmed:author | pubmed-author:Chazouillères... | lld:pubmed |
| pubmed-article:7904004 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7904004 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7904004 | pubmed:volume | 343 | lld:pubmed |
| pubmed-article:7904004 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7904004 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7904004 | pubmed:pagination | 142-6 | lld:pubmed |
| pubmed-article:7904004 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7904004 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7904004 | pubmed:articleTitle | "Occult" hepatitis B virus as source of infection in liver transplant recipients. | lld:pubmed |
| pubmed-article:7904004 | pubmed:affiliation | Department of Medicine, Department of Veterans Affairs, San Francisco, CA 94121. | lld:pubmed |
| pubmed-article:7904004 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7904004 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7904004 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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