| pubmed-article:7902287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C0379900 | lld:lifeskim |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:7902287 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:7902287 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:7902287 | pubmed:dateCreated | 1994-1-6 | lld:pubmed |
| pubmed-article:7902287 | pubmed:abstractText | This study was designed to determine if alpha 1-adrenoceptors are involved in the vascular responses to 5-HT1A receptor agonists. Buspirone (3.1 x 10(-7)-3.1 x 10(-5) M) and 8-hydroxy-2(di-N-propylamino)tetralin (8-OH-DPAT; 3.1 x 10(-6)-10(-4) M) elicited contractions of rabbit aorta rings which were blocked by prazosin (10(-9)-5.6 x 10(-9) M), but which were unaffected by reserpine pretreatment (1 mg/kg i.p.). 5-Methylurapidil (10(-7) and 10(-6) M) blocked contractions elicited by 8-OH-DPAT and by buspirone, whereas chloroethylchonidine (10(-5) and 10(-4) M) inhibited only the effect of buspirone. In addition, these 5-HT1A receptor agonists relaxed arteries precontracted with alpha-adrenoceptor agonists in a similar range of concentrations in which they elicited contraction. Moreover, 8-OH-DPAT and buspirone protected the alpha-adrenoceptors from the irreversible blockade provoked by phenoxybenzamine (10(-7) M), as judged by the norepinephrine contraction and stimulated phosphatidylinositol labeling. According to these results the contractile and relaxant effects elicited by 5-HT1A receptor agonists are a consequence of a direct interaction with alpha 1-adrenoceptors. The contraction elicited by 8-OH-DPAT may be mediated by alpha 1A-adrenoceptors, whereas both alpha 1A- and alpha 1B-adrenoceptors may mediate the effect of buspirone in rabbit aorta. | lld:pubmed |
| pubmed-article:7902287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7902287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7902287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7902287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7902287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7902287 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7902287 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:7902287 | pubmed:author | pubmed-author:HongEE | lld:pubmed |
| pubmed-article:7902287 | pubmed:author | pubmed-author:CastilloCC | lld:pubmed |
| pubmed-article:7902287 | pubmed:author | pubmed-author:Villalobos-Mo... | lld:pubmed |
| pubmed-article:7902287 | pubmed:author | pubmed-author:IbarraMM | lld:pubmed |
| pubmed-article:7902287 | pubmed:author | pubmed-author:MárquezJ AJA | lld:pubmed |
| pubmed-article:7902287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7902287 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:7902287 | pubmed:volume | 241 | lld:pubmed |
| pubmed-article:7902287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7902287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7902287 | pubmed:pagination | 141-8 | lld:pubmed |
| pubmed-article:7902287 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:meshHeading | pubmed-meshheading:7902287-... | lld:pubmed |
| pubmed-article:7902287 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7902287 | pubmed:articleTitle | Pharmacological evidence for interactions between 5-HT1A receptor agonists and subtypes of alpha 1-adrenoceptors on rabbit aorta. | lld:pubmed |
| pubmed-article:7902287 | pubmed:affiliation | Departamento de Farmacología y Toxicología, Centro de Investigación y Estudios, Avanzados del I.P.N., México, D.F. | lld:pubmed |
| pubmed-article:7902287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7902287 | pubmed:publicationType | In Vitro | lld:pubmed |
