| pubmed-article:7901111 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0029005 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0746922 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C2700445 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C2697524 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C1706163 | lld:lifeskim |
| pubmed-article:7901111 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7901111 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7901111 | pubmed:dateCreated | 1993-12-16 | lld:pubmed |
| pubmed-article:7901111 | pubmed:abstractText | In a retrospective study, paraffin-embedded tissues from 110 primary T1 breast carcinomas (tumour diameter < or = 2 cm) were examined for the presence of the Her-2/neu encoded oncoprotein p185neu, using an immunohistochemical technique. Primary surgical therapy revealed no node involvement in 76 cases. These patients did not receive an adjuvant systemic therapy. 25% of tumours were positive for p185neu. Expression of the oncoprotein was inversely correlated to oestrogen receptor status (p < 0.05). In patients with lymph node metastases and poorly differentiated tumours, the incidence of p185neu was higher than in node negative and/or well differentiated carcinomas. However, this finding was statistically not significant. No correlations were found between the detection of the oncoprotein and age, menopausal and progesterone receptor status. The median follow-up is 85 months. In patients without lymph node metastases (n = 76), presence of the oncoprotein was significantly correlated to a shorter relapse-free and/or overall survival (p < 0.05). No such correlation was found for 34 patients with lymph node involvement. Expression of p185neu seems to mark a group of T1N0 breast cancer patients, which is at high risk and might benefit from an adjuvant therapy. | lld:pubmed |
| pubmed-article:7901111 | pubmed:language | ger | lld:pubmed |
| pubmed-article:7901111 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7901111 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7901111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7901111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7901111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7901111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7901111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7901111 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7901111 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7901111 | pubmed:issn | 0016-5751 | lld:pubmed |
| pubmed-article:7901111 | pubmed:author | pubmed-author:ScharlAA | lld:pubmed |
| pubmed-article:7901111 | pubmed:author | pubmed-author:GöhringU JUJ | lld:pubmed |
| pubmed-article:7901111 | pubmed:author | pubmed-author:Aslan-Schadwi... | lld:pubmed |
| pubmed-article:7901111 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7901111 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:7901111 | pubmed:geneSymbol | p185neu | lld:pubmed |
| pubmed-article:7901111 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7901111 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7901111 | pubmed:pagination | 625-9 | lld:pubmed |
| pubmed-article:7901111 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
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| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:meshHeading | pubmed-meshheading:7901111-... | lld:pubmed |
| pubmed-article:7901111 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7901111 | pubmed:articleTitle | [Expression of the p185neu oncoprotein indicates an unfavorable prognosis in small, node negative breast cancer without systemic adjuvant treatment (T1N0)]. | lld:pubmed |
| pubmed-article:7901111 | pubmed:affiliation | Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universität zu Köln. | lld:pubmed |
| pubmed-article:7901111 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7901111 | pubmed:publicationType | English Abstract | lld:pubmed |
