| pubmed-article:7890377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7890377 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:7890377 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7890377 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:7890377 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7890377 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:7890377 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:7890377 | lifeskim:mentions | umls-concept:C0758434 | lld:lifeskim |
| pubmed-article:7890377 | lifeskim:mentions | umls-concept:C0758436 | lld:lifeskim |
| pubmed-article:7890377 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7890377 | pubmed:dateCreated | 1995-4-20 | lld:pubmed |
| pubmed-article:7890377 | pubmed:abstractText | A recombinant of toxic shock syndrome toxin 1 (TSST-1) which contains a single histidine-to-alanine mutation at residue 135 (H135A) was analyzed for toxicity and vaccine potential in a lipopolysaccharide (LPS)-potentiated mouse lethality model. The 50% lethal dose (LD50) of TSST-1 in BALB/c mice was 47.2 micrograms/kg, but H135A was not lethal when tested at a dose equivalent to 10 LD50s of TSST-1. Levels of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma) in serum were, respectively, 10- and 50-fold higher in LPS-potentiated mice injected with 15 LD50s of TSST-1 than in mice given H135A. Mice injected with only TSST-1 did not have elevated levels of TNF or IFN-gamma in serum, while H135A plus LPS or LPS alone elicited identical, yet very low, levels of TNF and IFN-gamma. An enzyme-linked immunosorbent assay of H135A and TSST-1 with anti-TSST-1 serum yielded very similar dose-response curves, which strongly suggests that H135A serologically and conformationally resembles the native toxin. Mice immunized with H135A developed antibodies that recognized TSST-1 in an enzyme-linked immunosorbent assay and afforded protection against a 15-LD50 challenge of TSST-1 plus LPS. The pooled sera of mice immunized with either TSST-1 or H135A also prevented lymphocyte proliferation due to TSST-1. | lld:pubmed |
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| pubmed-article:7890377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7890377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7890377 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7890377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7890377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7890377 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7890377 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:7890377 | pubmed:author | pubmed-author:BonventreP... | lld:pubmed |
| pubmed-article:7890377 | pubmed:author | pubmed-author:KrakauerTT | lld:pubmed |
| pubmed-article:7890377 | pubmed:author | pubmed-author:StilesB GBG | lld:pubmed |
| pubmed-article:7890377 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7890377 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:7890377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7890377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7890377 | pubmed:pagination | 1229-34 | lld:pubmed |
