| pubmed-article:7890234 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7890234 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:7890234 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:7890234 | lifeskim:mentions | umls-concept:C0021390 | lld:lifeskim |
| pubmed-article:7890234 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:7890234 | lifeskim:mentions | umls-concept:C0063717 | lld:lifeskim |
| pubmed-article:7890234 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:7890234 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7890234 | pubmed:dateCreated | 1995-4-18 | lld:pubmed |
| pubmed-article:7890234 | pubmed:abstractText | The in vivo appearance of soluble interleukin (IL)-6 receptor (sIL-6R) in serum from patients with inflammatory bowel disease was examined using an enzyme linked immunosorbent assay (ELISA). The serum sIL-6R concentrations in patients with active disease (ulcerative colitis, 148.4 (5.1); Crohn's disease, 142.3 (9.3) ng/ml; mean (SEM)) were significantly raised compared with those in patients with inactive disease (ulcerative colitis, 116.2 (7.2); Crohn's disease, 114.3 (7.1) ng/ml), some other type of colitis (104.8 (11.6) ng/ml), or in normal subjects (107.3 (2.4) ng/ml). These differences were also seen in paired samples examined during both active and inactive phases. Additionally, serum sIL-6R and IL-6 concentrations correlated significantly with C-reactive protein levels in both ulcerative colitis and Crohn's disease patients (r = 0.23 and 0.56, respectively; p < 0.05 for both). Furthermore, gel filtration analysis of serum from these patients showed two major peaks of immunoreactive IL-6-one peak corresponding to free IL-6 and another peak to sIL-6R-bound IL-6-this was further confirmed by a luminescence sandwich ELISA. These results, together with its in vitro effects, indicate that natural sIL-6R may function as a powerful enhancer of the IL-6-dependent immune processes observed in inflammatory bowel disease. | lld:pubmed |
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| pubmed-article:7890234 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7890234 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7890234 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7890234 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7890234 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7890234 | pubmed:issn | 0017-5749 | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:IkedaHH | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:IshidaOO | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:HaradaKK | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:NishiyamaTT | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:TanikawaKK | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:TateishiHH | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:SasakiEE | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:ToyonagaAA | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:TsurutaOO | lld:pubmed |
| pubmed-article:7890234 | pubmed:author | pubmed-author:MitsuyamaKK | lld:pubmed |
| pubmed-article:7890234 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7890234 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:7890234 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7890234 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7890234 | pubmed:pagination | 45-9 | lld:pubmed |
| pubmed-article:7890234 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7890234 | pubmed:meshHeading | pubmed-meshheading:7890234-... | lld:pubmed |
| pubmed-article:7890234 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7890234 | pubmed:articleTitle | Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6. | lld:pubmed |
| pubmed-article:7890234 | pubmed:affiliation | Second Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan. | lld:pubmed |
| pubmed-article:7890234 | pubmed:publicationType | Journal Article | lld:pubmed |
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