| pubmed-article:7889408 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7889408 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:7889408 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:7889408 | lifeskim:mentions | umls-concept:C0483191 | lld:lifeskim |
| pubmed-article:7889408 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:7889408 | lifeskim:mentions | umls-concept:C2246473 | lld:lifeskim |
| pubmed-article:7889408 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:7889408 | lifeskim:mentions | umls-concept:C2347644 | lld:lifeskim |
| pubmed-article:7889408 | lifeskim:mentions | umls-concept:C1552961 | lld:lifeskim |
| pubmed-article:7889408 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7889408 | pubmed:dateCreated | 1995-4-18 | lld:pubmed |
| pubmed-article:7889408 | pubmed:abstractText | In vivo thymocyte maturation models were used to investigate the differentiation role of Bcl-2. In alpha/beta T cell receptor (TCR) class II-restricted transgenic mice, Bcl-2 was upregulated at the CD4+ CD8+ stage during positive selection. The lckpr-bcl2 transgene was bred onto MHC classes I-I- and II-I-, MHC-I-, and alpha/beta TCR backgrounds to determine whether Bcl-2 promoted thymocyte maturation in the absence of coreceptor-MHC interaction. Bcl-2 rescued CD8+ thymocytes in class I-I- and alpha/beta TCR in mice; however, they were not exported to the periphery. Bcl-2 had no effect on CD4 lineage maturation in class II-I- mice. No single-positive thymocytes accumulate in MHC-I- mice despite overexpressed Bcl-2. Thus, Bcl-2 enables selection of certain TCRs on class II molecules and their differentiation along the CD8 pathway; however, Bcl-2 did not substitute for positive selection. In RAG-1-I- mice, Bcl-2 promoted differentiation to the CD4+ CD8+ stage. Bcl-2 can promote thymocyte maturation at several control points. | lld:pubmed |
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| pubmed-article:7889408 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7889408 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7889408 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7889408 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7889408 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:7889408 | pubmed:author | pubmed-author:HansenT HTH | lld:pubmed |
| pubmed-article:7889408 | pubmed:author | pubmed-author:HedrickS MSM | lld:pubmed |
| pubmed-article:7889408 | pubmed:author | pubmed-author:KorsmeyerS... | lld:pubmed |
| pubmed-article:7889408 | pubmed:author | pubmed-author:GlimcherL HLH | lld:pubmed |
| pubmed-article:7889408 | pubmed:author | pubmed-author:LinetteG PGP | lld:pubmed |
| pubmed-article:7889408 | pubmed:author | pubmed-author:GrusbyM JMJ | lld:pubmed |
| pubmed-article:7889408 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7889408 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:7889408 | pubmed:geneSymbol | lck<up>pr</up> | lld:pubmed |
| pubmed-article:7889408 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7889408 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7889408 | pubmed:pagination | 197-205 | lld:pubmed |
| pubmed-article:7889408 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7889408 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7889408 | pubmed:articleTitle | Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. | lld:pubmed |
| pubmed-article:7889408 | pubmed:affiliation | Howard Hughes Medical Institute, Department of Medicine and Pathology, Washington University School of Medicine, St. Louis, Missouri 63110. | lld:pubmed |
| pubmed-article:7889408 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7889408 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7889408 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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