| pubmed-article:7889269 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7889269 | lifeskim:mentions | umls-concept:C2917290 | lld:lifeskim |
| pubmed-article:7889269 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7889269 | pubmed:dateCreated | 1995-4-19 | lld:pubmed |
| pubmed-article:7889269 | pubmed:abstractText | 1. (-)-Deprenyl has been shown to potentiate rat striatal neurone responses to dopamine agonists at doses not altering dopamine metabolism. Since there are a number of effects of (-)-deprenyl which could result in this phenomenon, we have investigated the effects of MDL 72,145 and Ro 19-6327, whose only common effect with (-)-deprenyl is an inhibition of monoamine oxidase-B (MAO-B), on rat striatal neurone responses to dopamine and on striatal dopamine metabolism. 2. Using in vivo electrophysiology, i.p. injection of either MDL 72,145 or Ro 19-6327 was found to produce a dose-dependent potentiation of striatal neurone responses to dopamine but not gamma-aminobutyric acid. 3. Neurochemical investigations revealed that this occurred at doses (0.25-1 mg kg-1) which, while not affecting levels of dopamine or its metabolites, 3,4-dihydroxyphenylacetic acid or homovanillic acid, did cause a significant, dose-dependent, elevation in striatal levels of the putative neuromodulator, 2-phenylethylamine (PE). 4. Inhibition of PE synthesis by i.p. injection of the aromatic L-amino acid decarboxylase inhibitor, NSD 1015, produced a reversal of the effects of MDL 72,145 and Ro 19-6327. 5. Neurochemical analysis revealed this to occur at a dose of NSD 1015 (10 mg kg-1) selective for reduction of elevated PE levels. 6. These results suggest that PE can act as a neuromodulator of dopaminergic responses and that MAO-B inhibitors may potentiate neuronal responses to dopamine via the indirect mechanism of elevation of PE following MAO-B inhibition. | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7889269 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7889269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7889269 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7889269 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7889269 | pubmed:author | pubmed-author:LeeY TYT | lld:pubmed |
| pubmed-article:7889269 | pubmed:author | pubmed-author:JuorioA VAV | lld:pubmed |
| pubmed-article:7889269 | pubmed:author | pubmed-author:PatersonI AIA | lld:pubmed |
| pubmed-article:7889269 | pubmed:author | pubmed-author:BerryM DMD | lld:pubmed |
| pubmed-article:7889269 | pubmed:author | pubmed-author:ScarrEE | lld:pubmed |
| pubmed-article:7889269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7889269 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:7889269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7889269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7889269 | pubmed:pagination | 1159-66 | lld:pubmed |
| pubmed-article:7889269 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:meshHeading | pubmed-meshheading:7889269-... | lld:pubmed |
| pubmed-article:7889269 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7889269 | pubmed:articleTitle | The effects of administration of monoamine oxidase-B inhibitors on rat striatal neurone responses to dopamine. | lld:pubmed |
| pubmed-article:7889269 | pubmed:affiliation | Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada. | lld:pubmed |
| pubmed-article:7889269 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7889269 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7889269 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7889269 | lld:pubmed |
