| pubmed-article:7882030 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0002302 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0079883 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:7882030 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:7882030 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7882030 | pubmed:dateCreated | 1995-4-13 | lld:pubmed |
| pubmed-article:7882030 | pubmed:abstractText | Superfusion of rat hypothalamic slices with 10(-4) M N-methyl-D-aspartic acid (NMDA) resulted in increased release of alpha-melanocyte-stimulating hormone (alpha-MSH). Peptide release was blocked by 10(-6) M NG-nitro-L-arginine methyl ester (L-NAME) a specific competitive inhibitor of nitric oxide synthase but not by the inactive enantiomer D-NAME at 10(-6) M. The inhibition by L-NAME was reversed by the addition of 10(-5) mM L-arginine, an excess of enzyme substrate. Release of nitric oxide products into tissue superfusates was stimulated by a 50 mM concentration of potassium ions and by 10(-4) M NMDA. Potassium-stimulated release was blocked by L-NAME. Basal, potassium-stimulated and NMDA-stimulated release of nitric oxide products were significantly inhibited by the NMDA-receptor antagonist D(-)-2-amino-5-phosphopentanoic acid (AP5) at 10(-4) M and by the NMDA-channel blocker ketamine at 10(-4) M. We conclude that nitric oxide mediates the stimulatory action of glutamic acid on the release of alpha-MSH from the rat hypothalamus. | lld:pubmed |
| pubmed-article:7882030 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7882030 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7882030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7882030 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7882030 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7882030 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:7882030 | pubmed:author | pubmed-author:WilsonJ FJF | lld:pubmed |
| pubmed-article:7882030 | pubmed:author | pubmed-author:WaymanC PCP | lld:pubmed |
| pubmed-article:7882030 | pubmed:author | pubmed-author:PikeN VNV | lld:pubmed |
| pubmed-article:7882030 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7882030 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7882030 | pubmed:volume | 666 | lld:pubmed |
| pubmed-article:7882030 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7882030 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7882030 | pubmed:pagination | 201-6 | lld:pubmed |
| pubmed-article:7882030 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:meshHeading | pubmed-meshheading:7882030-... | lld:pubmed |
| pubmed-article:7882030 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7882030 | pubmed:articleTitle | N-methyl-D-aspartate (NMDA) stimulates release of alpha-MSH from the rat hypothalamus through release of nitric oxide. | lld:pubmed |
| pubmed-article:7882030 | pubmed:affiliation | Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Health Park, Cardiff, UK. | lld:pubmed |
| pubmed-article:7882030 | pubmed:publicationType | Journal Article | lld:pubmed |
