| pubmed-article:7881273 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7881273 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:7881273 | lifeskim:mentions | umls-concept:C0002520 | lld:lifeskim |
| pubmed-article:7881273 | lifeskim:mentions | umls-concept:C0333051 | lld:lifeskim |
| pubmed-article:7881273 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7881273 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:7881273 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:7881273 | lifeskim:mentions | umls-concept:C0599218 | lld:lifeskim |
| pubmed-article:7881273 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:7881273 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7881273 | pubmed:dateCreated | 1995-4-11 | lld:pubmed |
| pubmed-article:7881273 | pubmed:abstractText | In this study we report on the 1H, 13C and 15N NMR chemical shifts for the random coil state and nearest-neighbor sequence effects measured from the protected linear hexapeptide Gly-Gly-X-Y-Gly-Gly (where X and Y are any of the 20 common amino acids). We present data for a set of 40 peptides (of the possible 400) including Gly-Gly-X-Ala-Gly-Gly and Gly-Gly-X-Pro-Gly-Gly, measured under identical aqueous conditions. Because all spectra were collected under identical experimental conditions, the data from the Gly-Gly-X-Ala-Gly-Gly series provide a complete and internally consistent set of 1H, 13C and 15N random coil chemical shifts for all 20 common amino acids. In addition, studies were also conducted into nearest-neighbor effects on the random coil shift arising from a variety of X and Y positional substitutions. Comparisons between the chemical shift measurements obtained from Gly-Gly-X-Ala-Gly-Gly and Gly-Gly-X-Pro-Gly-Gly reveal significant systematic shift differences arising from the presence of proline in the peptide sequence. Similarly, measurements of the chemical shift changes occurring for both alanine and proline (i.e., the residues in the Y position) are found to depend strongly on the type of amino acid substituted into the X position. These data lend support to the hypothesis that sequence effects play a significant role in determining peptide and protein chemical shifts. | lld:pubmed |
| pubmed-article:7881273 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7881273 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7881273 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7881273 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7881273 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7881273 | pubmed:issn | 0925-2738 | lld:pubmed |
| pubmed-article:7881273 | pubmed:author | pubmed-author:SykesB DBD | lld:pubmed |
| pubmed-article:7881273 | pubmed:author | pubmed-author:HodgesR SRS | lld:pubmed |
| pubmed-article:7881273 | pubmed:author | pubmed-author:HolmAA | lld:pubmed |
| pubmed-article:7881273 | pubmed:author | pubmed-author:WishartD SDS | lld:pubmed |
| pubmed-article:7881273 | pubmed:author | pubmed-author:BigamC GCG | lld:pubmed |
| pubmed-article:7881273 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7881273 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:7881273 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7881273 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7881273 | pubmed:pagination | 67-81 | lld:pubmed |
| pubmed-article:7881273 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7881273 | pubmed:meshHeading | pubmed-meshheading:7881273-... | lld:pubmed |
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| pubmed-article:7881273 | pubmed:meshHeading | pubmed-meshheading:7881273-... | lld:pubmed |
| pubmed-article:7881273 | pubmed:meshHeading | pubmed-meshheading:7881273-... | lld:pubmed |
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| pubmed-article:7881273 | pubmed:meshHeading | pubmed-meshheading:7881273-... | lld:pubmed |
| pubmed-article:7881273 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7881273 | pubmed:articleTitle | 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects. | lld:pubmed |
| pubmed-article:7881273 | pubmed:affiliation | Department of Biochemistry, University of Alberta, Edmonton, Canada. | lld:pubmed |
| pubmed-article:7881273 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7881273 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7881273 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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