[Participation of benzodiazepine receptors in the mechanism of action of nicotinamide in nerve cells].

Source:http://linkedlifedata.com/resource/pubmed/id/7879292

Download in:

View as

General Info

Authors

Parkhomets PK, Fomenko AI, Donchenko GV, Stepanenko SP

Abstract

Bicucculine being introduced to rats has induced an increase of [14C]GABA capture with synaptosomes and simultaneous decrease of GABA and NAD level in the brain. The decrease of the inhibiting effect of GABA is accompanied by the increase of specific binding of [3H]flunitrazepam with benzodiazepine receptors at the expense of the increase of binding capacity from 0.33 to 0.45 g/mol per 100 mg of protein. Under these conditions the dissociation constant remains unchanged. Such an activation of benzodiazepine receptors was observed under the lack of NAD in the organism (model of PP-hypovitaminosis). Introduction of the surplus doses of nicotinamide neutralizes the convulsant effect on benzodiazepine receptors.

PMID
7879292