| pubmed-article:7876182 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7876182 | lifeskim:mentions | umls-concept:C0087140 | lld:lifeskim |
| pubmed-article:7876182 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:7876182 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:7876182 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:7876182 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7876182 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7876182 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:7876182 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7876182 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7876182 | pubmed:dateCreated | 1995-4-5 | lld:pubmed |
| pubmed-article:7876182 | pubmed:abstractText | A mechanism by which voltage-sensitive Ca2+ channel (VSCC) activation triggers c-fos transcription has been characterized. Ca2+ influx through VSCCs stimulates phosphorylation of the transcription factor cAMP response element-binding protein (CREB) on serine 133 leading to an increase in the formation of transcription complexes that can elongate through a transcription pause site within the c-fos gene. Ca(2+)-stimulated CREB serine 133 phosphorylation is mediated by a Ca(2+)-activated kinase and is not dependent on the cAMP-dependent protein kinase (PKA). While necessary for c-fos transcriptional induction following VSCC opening, CREB serine 133 phosphorylation is not sufficient for transcriptional activation. A second, PKA-dependent event is required. Following induction, c-fos transcription is rapidly down-regulated. Dephosphorylation of CREB serine 133 parallels and likely mediates the transcriptional shut-off event. These results suggest that the phosphorylation and dephosphorylation of CREB controls its ability to regulate transcription in membrane-depolarized cells and that multiple pathways contribute to Ca(2+)-activated gene expression. | lld:pubmed |
| pubmed-article:7876182 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876182 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7876182 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876182 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7876182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7876182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876182 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7876182 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7876182 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7876182 | pubmed:author | pubmed-author:ThompsonM AMA | lld:pubmed |
| pubmed-article:7876182 | pubmed:author | pubmed-author:GreenbergM... | lld:pubmed |
| pubmed-article:7876182 | pubmed:author | pubmed-author:GintyD DDD | lld:pubmed |
| pubmed-article:7876182 | pubmed:author | pubmed-author:BonneEE | lld:pubmed |
| pubmed-article:7876182 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7876182 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:7876182 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7876182 | pubmed:geneSymbol | c-fos | lld:pubmed |
| pubmed-article:7876182 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7876182 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7876182 | pubmed:pagination | 4224-35 | lld:pubmed |
| pubmed-article:7876182 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7876182 | pubmed:meshHeading | pubmed-meshheading:7876182-... | lld:pubmed |
| pubmed-article:7876182 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7876182 | pubmed:articleTitle | L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels. | lld:pubmed |
| pubmed-article:7876182 | pubmed:affiliation | Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115. | lld:pubmed |
| pubmed-article:7876182 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7876182 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7876182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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