| pubmed-article:7876106 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7876106 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7876106 | lifeskim:mentions | umls-concept:C0209548 | lld:lifeskim |
| pubmed-article:7876106 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:7876106 | lifeskim:mentions | umls-concept:C1420801 | lld:lifeskim |
| pubmed-article:7876106 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:7876106 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7876106 | lifeskim:mentions | umls-concept:C0205117 | lld:lifeskim |
| pubmed-article:7876106 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7876106 | pubmed:dateCreated | 1995-3-31 | lld:pubmed |
| pubmed-article:7876106 | pubmed:abstractText | Tumor necrosis factor (TNF)-stimulated gene 6 (TSG-6) encodes a protein expressed during inflammation. We have previously shown that transcription factors of the NF-IL6 and AP-1 families cooperatively modulate activation of the TSG-6 gene by TNF or interleukin 1 (IL-1) through a promoter region that contains an NF-IL6 site (-106 to -114) and an AP-1 element (-126 to -119). In this study we report the identification of an additional NF-IL6 site (NF-IL6*) located at positions -92 to -83. Footprinting and electrophoretic mobility shift assay suggested that NF-IL6 binds with higher affinity to the newly identified NF-IL6* site than to the earlier identified promoter-distal NF-IL6 site and that the two sites cooperate in binding NF-IL6. TNF and IL-1 stimulate specific binding of nuclear proteins to the NF-IL6* site more efficiently than to the promoter-distal NF-IL6 site. Moreover, a mutation in the NF-IL6* site abolished transactivation of the TSG-6 promoter by NF-IL6 despite the presence of the intact promoter-distal NF-IL6 site. A mutation in the promoter-distal NF-IL6 site also greatly decreased activation of the TSG-6 promoter by NF-IL6. We conclude that the two NF-IL6 sites are functionally interdependent in the activation of the TSG-6 gene. | lld:pubmed |
| pubmed-article:7876106 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7876106 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7876106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7876106 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7876106 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7876106 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7876106 | pubmed:author | pubmed-author:VilcekJJ | lld:pubmed |
| pubmed-article:7876106 | pubmed:author | pubmed-author:Chen-KiangSS | lld:pubmed |
| pubmed-article:7876106 | pubmed:author | pubmed-author:KlampferLL | lld:pubmed |
| pubmed-article:7876106 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7876106 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:7876106 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7876106 | pubmed:geneSymbol | TSG-6 | lld:pubmed |
| pubmed-article:7876106 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7876106 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7876106 | pubmed:pagination | 3677-82 | lld:pubmed |
| pubmed-article:7876106 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:meshHeading | pubmed-meshheading:7876106-... | lld:pubmed |
| pubmed-article:7876106 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7876106 | pubmed:articleTitle | Activation of the TSG-6 gene by NF-IL6 requires two adjacent NF-IL6 binding sites. | lld:pubmed |
| pubmed-article:7876106 | pubmed:affiliation | Department of Microbiology, New York University Medical Center, New York 10016. | lld:pubmed |
| pubmed-article:7876106 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7876106 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7876106 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7876106 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7876106 | lld:pubmed |
