| pubmed-article:7874504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7874504 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7874504 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7874504 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:7874504 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:7874504 | lifeskim:mentions | umls-concept:C0118325 | lld:lifeskim |
| pubmed-article:7874504 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7874504 | pubmed:dateCreated | 1995-4-6 | lld:pubmed |
| pubmed-article:7874504 | pubmed:abstractText | Funnel web spider toxin (FTX) is reportedly a specific blocker of P-type Ca2+ channels. The effects of FTX on the Ca2+ currents of isolated neurohypophysial nerve terminals of the rat were investigated using the 'whole-cell' patch-clamp technique. Both the transient and long-lasting Ca2+ current components were maximally elicited by depolarization from a holding potential equal to the normal terminal resting potential (-90 mV). Externally applied FTX inhibited the high-voltage-threshold, transient component of the Ca2+ current in a concentration-dependent manner, with a half-maximal inhibition at a dilution of approximately 1:10000. FTX also shifted the peak current of the I-V relationship by +10 mV. The long-lasting Ca2+ current component, which is sensitive to L-type Ca2+ channel blockers, was insensitive to FTX. The transient current, which is sensitive to omega-conotoxin GVIA, was completely blocked by FTX. These results suggest that there could be a novel, inactivating Ca2+ channel in the rat neurohypophysial terminals which is affected by both N-type and P-type Ca2+ channel blockers. | lld:pubmed |
| pubmed-article:7874504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7874504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7874504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7874504 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7874504 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:7874504 | pubmed:author | pubmed-author:WangGG | lld:pubmed |
| pubmed-article:7874504 | pubmed:author | pubmed-author:LemosJ RJR | lld:pubmed |
| pubmed-article:7874504 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7874504 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:7874504 | pubmed:volume | 663 | lld:pubmed |
| pubmed-article:7874504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7874504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7874504 | pubmed:pagination | 215-22 | lld:pubmed |
| pubmed-article:7874504 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
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| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:meshHeading | pubmed-meshheading:7874504-... | lld:pubmed |
| pubmed-article:7874504 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7874504 | pubmed:articleTitle | Effects of funnel web spider toxin on Ca2+ currents in neurohypophysial terminals. | lld:pubmed |
| pubmed-article:7874504 | pubmed:affiliation | Worcester Foundation for Experimental Biology, Shrewsbury, MA 01545. | lld:pubmed |
| pubmed-article:7874504 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7874504 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7874504 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7874504 | lld:pubmed |
