| pubmed-article:7873203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C1273518 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:7873203 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7873203 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7873203 | pubmed:dateCreated | 1995-4-5 | lld:pubmed |
| pubmed-article:7873203 | pubmed:abstractText | Because interleukin-1 beta (IL-1 beta) increases the synthesis of prostaglandin E2 (PGE2) in human lung fibroblasts, the effect of IL-1 beta on the expression of two isozymes of cyclooxygenase (cyclooxygenase-1 and -2) in human embryonic lung fibroblasts (IMR-90) was investigated in terms of three parameters (PGE2 release, cyclooxygenase activity, and mRNA). When the cells were incubated with IL-1 beta, both the PGE2 release to the culture medium and the cyclooxygenase activity in the cell lysate increased in a dose- and time-dependent manner, and both were inhibited by NS-398 (a cyclooxygenase-2-specific inhibitor). Dexamethasone and interleukin-4 (IL-4) inhibited the IL-1 beta-induced PGE2 synthesis; the former inhibited the IL-1 beta-induced cyclooxygenase activity whereas the latter failed. As analyzed by Northern blot, cyclooxygenase-1 mRNAs (3.0 Kb and 5.0 Kb) were detected with resting cells and did not increase by the addition of IL-1 beta. In contrast, the cyclooxygenase-2 mRNA (4.4 Kb) was undetectable with resting cells, but was increased dramatically up to 4 to 8 h by the addition of IL-1 beta. Dexamethasone inhibited the IL-1 beta-induced mRNA expression of cyclooxygenase-2 whereas IL-4 failed. These results indicate that IL-1 beta induces cyclooxygenase-2 rather than cyclooxygenase-1 in IMR-90 cells and this induction is responsible for the augmentation of PGE2 production stimulated with IL-1 beta. However, the inhibition of the IL-1 beta-induced PGE2 synthesis by IL-4 was not mediated by the down-regulation of cyclooxygenase-2. | lld:pubmed |
| pubmed-article:7873203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7873203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7873203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7873203 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7873203 | pubmed:issn | 1044-1549 | lld:pubmed |
| pubmed-article:7873203 | pubmed:author | pubmed-author:EndoTT | lld:pubmed |
| pubmed-article:7873203 | pubmed:author | pubmed-author:UedaNN | lld:pubmed |
| pubmed-article:7873203 | pubmed:author | pubmed-author:HayashiYY | lld:pubmed |
| pubmed-article:7873203 | pubmed:author | pubmed-author:YamamotoSS | lld:pubmed |
| pubmed-article:7873203 | pubmed:author | pubmed-author:OguraTT | lld:pubmed |
| pubmed-article:7873203 | pubmed:author | pubmed-author:OgushiFF | lld:pubmed |
| pubmed-article:7873203 | pubmed:author | pubmed-author:SoneSS | lld:pubmed |
| pubmed-article:7873203 | pubmed:author | pubmed-author:TaketaniYY | lld:pubmed |
| pubmed-article:7873203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7873203 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:7873203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7873203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7873203 | pubmed:pagination | 358-65 | lld:pubmed |
| pubmed-article:7873203 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:meshHeading | pubmed-meshheading:7873203-... | lld:pubmed |
| pubmed-article:7873203 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7873203 | pubmed:articleTitle | Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts. | lld:pubmed |
| pubmed-article:7873203 | pubmed:affiliation | Third Department of Internal Medicine, School of Medicine, Tokushima University, Japan. | lld:pubmed |
| pubmed-article:7873203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7873203 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7873203 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7873203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7873203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7873203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7873203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7873203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7873203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7873203 | lld:pubmed |
