| pubmed-article:7870057 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7870057 | lifeskim:mentions | umls-concept:C0025011 | lld:lifeskim |
| pubmed-article:7870057 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:7870057 | lifeskim:mentions | umls-concept:C0042717 | lld:lifeskim |
| pubmed-article:7870057 | lifeskim:mentions | umls-concept:C0079600 | lld:lifeskim |
| pubmed-article:7870057 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:7870057 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7870057 | pubmed:dateCreated | 1995-3-27 | lld:pubmed |
| pubmed-article:7870057 | pubmed:abstractText | The generation of a sustained antibody response requires the participation of MHC class II-restricted T helper cells. We have identified class II-restricted sequences by immunizing BALB/c (H-2d) mice with 108 overlapping synthetic pentadecapeptides covering the whole sequence of the measles virus fusion protein (MV-F). Several strong T cell epitopes were found including a major cluster of H-2d-restricted peptides between amino acids 256 and 305. Some of these peptides including peptide F(421-435) and F(256-270) induced MV-specific T lymphocytes in vivo while other H2d-restricted MV-F sequences did not. Immunization with mixtures of selected peptides indicated a hierarchy among H2d-restricted sequences due to competition between peptides. The dominant peptide F(421-435) impaired the response to other T cell epitopes including F(256-270). The response to F(91-105) was obliterated by F(421-435) and F(256-270) but not by peptides devoid of a T cell epitope. When BALB/c mice were immunized with the MV, the immunodominant sequence F(421-445) was identified which included the synthetic peptide F(421-435). Our data suggest that competition during processing and/or presentation between H2d-restricted peptides defines the immunodominant sequence of the viral protein. Even though only a single immunodominant region was defined after immunization with the MV, peptides from other regions were able to induce MV-specific T cell responses. This finding is of interest for the design of subunit vaccines in general and for studying MV-specific T helper cells in an animal model in particular. | lld:pubmed |
| pubmed-article:7870057 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7870057 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7870057 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7870057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7870057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7870057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7870057 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7870057 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7870057 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7870057 | pubmed:issn | 0161-5890 | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:SchneiderFF | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:JungGG | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:BronsN HNH | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:WiesmüllerK... | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:MullerC PCP | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:WeinmannMM | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:AmmonSS | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:GanderRR | lld:pubmed |
| pubmed-article:7870057 | pubmed:author | pubmed-author:MayserHH | lld:pubmed |
| pubmed-article:7870057 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7870057 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:7870057 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7870057 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7870057 | pubmed:pagination | 37-47 | lld:pubmed |
| pubmed-article:7870057 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7870057 | pubmed:meshHeading | pubmed-meshheading:7870057-... | lld:pubmed |
| pubmed-article:7870057 | pubmed:meshHeading | pubmed-meshheading:7870057-... | lld:pubmed |
| pubmed-article:7870057 | pubmed:meshHeading | pubmed-meshheading:7870057-... | lld:pubmed |
| pubmed-article:7870057 | pubmed:meshHeading | pubmed-meshheading:7870057-... | lld:pubmed |
| pubmed-article:7870057 | pubmed:meshHeading | pubmed-meshheading:7870057-... | lld:pubmed |
| pubmed-article:7870057 | pubmed:meshHeading | pubmed-meshheading:7870057-... | lld:pubmed |
| pubmed-article:7870057 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7870057 | pubmed:articleTitle | Intramolecular immunodominance and intermolecular selection of H2d-restricted peptides define the same immunodominant region of the measles virus fusion protein. | lld:pubmed |
| pubmed-article:7870057 | pubmed:affiliation | Laboratoire National de Santé, Luxembourg. | lld:pubmed |
| pubmed-article:7870057 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7870057 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7870057 | lld:pubmed |
