Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:7866986rdf:typepubmed:Citationlld:pubmed
pubmed-article:7866986lifeskim:mentionsumls-concept:C0024109lld:lifeskim
pubmed-article:7866986lifeskim:mentionsumls-concept:C1510707lld:lifeskim
pubmed-article:7866986lifeskim:mentionsumls-concept:C0001430lld:lifeskim
pubmed-article:7866986lifeskim:mentionsumls-concept:C0080194lld:lifeskim
pubmed-article:7866986lifeskim:mentionsumls-concept:C0032458lld:lifeskim
pubmed-article:7866986lifeskim:mentionsumls-concept:C0242958lld:lifeskim
pubmed-article:7866986lifeskim:mentionsumls-concept:C0441889lld:lifeskim
pubmed-article:7866986lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:7866986pubmed:issue5lld:pubmed
pubmed-article:7866986pubmed:dateCreated1995-3-30lld:pubmed
pubmed-article:7866986pubmed:abstractTextThe induction of DNA adducts and adenomas in the lungs of strain A/J mice has been investigated following the single i.p. administration of each of the following polycyclic aromatic hydrocarbons (PAH): pyrene, dibenz[a,h]anthracene, benzo[a]pyrene, benzo[b]fluoranthene, 5-methylchrysene, and cyclopenta[c,d]pyrene. DNA adducts were measured by 32P-postlabeling at times between 1 and 21 days following injection, while adenomas were counted at 240 days after treatment. Pyrene did not induce either DNA adducts or lung adenomas at any of the doses examined. Each of the remaining PAH induced both adenomas and DNA adducts in a dose-dependent manner, with dibenz[a,h]anthracene > 5-methylchrysene > cyclopenta[c,d]pyrene > benzo[a]pyrene > benzo[b]fluoranthene. DNA adducts reached maximal levels between 3 and 9 days after injection, followed by a gradual decrease. The time-integrated DNA adduct level (TIDAL) was calculated by numerically integrating the areas under the adduct persistence curves extrapolated to 240 days for each PAH at each dose level. This value represents the effective total molecular dose of PAH that was delivered to the lung DNA over the entire course of tumorigenesis. A strong correlation of lung adenoma induction with the TIDAL values was observed for each PAH. The slopes of the tumors versus TIDAL value relationships were essentially identical for 5-methylchrysene, cyclopenta[cd]pyrene, benzo[a]pyrene, and benzo[b]fluoranthene. The slope of this relationship for dibenz[a,h]anthracene was markedly greater. The essentially identical induction of adenomas as a function of TIDAL values for these PAH suggests that the formation and persistence of DNA adducts determines their carcinogenic potency.lld:pubmed
pubmed-article:7866986pubmed:languageenglld:pubmed
pubmed-article:7866986pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7866986pubmed:citationSubsetIMlld:pubmed
pubmed-article:7866986pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7866986pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7866986pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7866986pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7866986pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7866986pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7866986pubmed:statusMEDLINElld:pubmed
pubmed-article:7866986pubmed:monthMarlld:pubmed
pubmed-article:7866986pubmed:issn0008-5472lld:pubmed
pubmed-article:7866986pubmed:authorpubmed-author:NesnowSSlld:pubmed
pubmed-article:7866986pubmed:authorpubmed-author:StonerG DGDlld:pubmed
pubmed-article:7866986pubmed:authorpubmed-author:WilsonK HKHlld:pubmed
pubmed-article:7866986pubmed:authorpubmed-author:RossJ AJAlld:pubmed
pubmed-article:7866986pubmed:authorpubmed-author:GalatiAAlld:pubmed
pubmed-article:7866986pubmed:authorpubmed-author:MassM JMJlld:pubmed
pubmed-article:7866986pubmed:authorpubmed-author:RabinowitzJ...lld:pubmed
pubmed-article:7866986pubmed:authorpubmed-author:NelsonG BGBlld:pubmed
pubmed-article:7866986pubmed:issnTypePrintlld:pubmed
pubmed-article:7866986pubmed:day1lld:pubmed
pubmed-article:7866986pubmed:volume55lld:pubmed
pubmed-article:7866986pubmed:ownerNLMlld:pubmed
pubmed-article:7866986pubmed:authorsCompleteYlld:pubmed
pubmed-article:7866986pubmed:pagination1039-44lld:pubmed
pubmed-article:7866986pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:meshHeadingpubmed-meshheading:7866986-...lld:pubmed
pubmed-article:7866986pubmed:year1995lld:pubmed
pubmed-article:7866986pubmed:articleTitleAdenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels.lld:pubmed
pubmed-article:7866986pubmed:affiliationCarcinogenesis and Metabolism Branch, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.lld:pubmed
pubmed-article:7866986pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7866986pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7866986lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7866986lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7866986lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7866986lld:pubmed