| pubmed-article:7851662 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7851662 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:7851662 | lifeskim:mentions | umls-concept:C0022674 | lld:lifeskim |
| pubmed-article:7851662 | lifeskim:mentions | umls-concept:C0023870 | lld:lifeskim |
| pubmed-article:7851662 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:7851662 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7851662 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:7851662 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7851662 | pubmed:dateCreated | 1995-3-16 | lld:pubmed |
| pubmed-article:7851662 | pubmed:abstractText | Kidney tubules develop by a mesenchyme-epithelium transition, normally induced by ureteric bud through a mechanism that remains obscure. Murine nephrogenesis in vitro has always required heterologous inducing cells. We have discovered that Li+ can elicit the early stages of epithelial differentiation in isolated nephrogenic mesenchyme. We have made detailed comparisons of the timing of morphoregulatory molecule expression between Li(+)-mediated induction and the traditional in vitro method using induction by spinal cord. Both followed the same program of early morphoregulatory molecule expression, though Li(+)-induced samples failed to progress into the later parts of the nephrogenic process. Mesenchymes induced by Li+ showed more DNA synthesis than controls, though less than those induced by spinal cord. Discovery of a chemical means to activate differentiation in the absence of heterologous tissue offers a new basis for studying molecular mechanisms regulating the early events of nephrogenesis, as well as for investigating transduction of inductive signals that initiate the process. | lld:pubmed |
| pubmed-article:7851662 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7851662 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7851662 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7851662 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7851662 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7851662 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7851662 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7851662 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7851662 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:7851662 | pubmed:author | pubmed-author:DaviesJ AJA | lld:pubmed |
| pubmed-article:7851662 | pubmed:author | pubmed-author:GarrodD RDR | lld:pubmed |
| pubmed-article:7851662 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7851662 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:7851662 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7851662 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7851662 | pubmed:pagination | 50-60 | lld:pubmed |
| pubmed-article:7851662 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7851662 | pubmed:meshHeading | pubmed-meshheading:7851662-... | lld:pubmed |
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| pubmed-article:7851662 | pubmed:meshHeading | pubmed-meshheading:7851662-... | lld:pubmed |
| pubmed-article:7851662 | pubmed:meshHeading | pubmed-meshheading:7851662-... | lld:pubmed |
| pubmed-article:7851662 | pubmed:meshHeading | pubmed-meshheading:7851662-... | lld:pubmed |
| pubmed-article:7851662 | pubmed:meshHeading | pubmed-meshheading:7851662-... | lld:pubmed |
| pubmed-article:7851662 | pubmed:meshHeading | pubmed-meshheading:7851662-... | lld:pubmed |
| pubmed-article:7851662 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7851662 | pubmed:articleTitle | Induction of early stages of kidney tubule differentiation by lithium ions. | lld:pubmed |
| pubmed-article:7851662 | pubmed:affiliation | Cancer Research Campaign Epithelial Morphogenesis Research Group, School of Biological Sciences, University of Manchester, United Kingdom. | lld:pubmed |
| pubmed-article:7851662 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7851662 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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