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pubmed-article:7846948pubmed:abstractTextThe role of cardiac glycosides for conversion of atrial fibrillation to simus rhythm is controversially discussed. In a prospective study, 45 patients with paroxysmal atrial fibrillation were randomly assigned to one of three treatment groups (of 15 patients each). Group I received oral digoxin, three times 0.125 mg up to twice 0.25 mg daily; group II oral digoxin twice 0.125 mg and quinidine hydrogen sulphate 750-1000 mg daily; group III oral digoxin three times 0.125 mg and flecaimide 200-300 mg daily. During a mean observation period of 11 months, digoxin alone was significantly less effective (p < 0.05) in reducing or suppressing paroxyms of atrial fibrillation than digoxin plus quinidine or flecainide. The use of digoxin remains a mainstay of treatment for rate control in atrial fibrillation. To convert atrial fibrillation to sinus rhythm, however, the addition of a type I or III antiarrhythmic agent is necessary.lld:pubmed
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pubmed-article:7846948pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:7846948pubmed:articleTitle[The use of digitalis glycosides in atrial fibrillation].lld:pubmed
pubmed-article:7846948pubmed:affiliationMedizinische Klinik I, Universität München, Klinikum Grosshadern.lld:pubmed
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