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| pubmed-article:7840594 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:7840594 | lifeskim:mentions | umls-concept:C0036956 | lld:lifeskim |
| pubmed-article:7840594 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7840594 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:7840594 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:7840594 | lifeskim:mentions | umls-concept:C0032520 | lld:lifeskim |
| pubmed-article:7840594 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:7840594 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7840594 | pubmed:dateCreated | 1995-3-2 | lld:pubmed |
| pubmed-article:7840594 | pubmed:abstractText | To study 4-quinolone resistance, the N-terminal coding region of gyrA from nalidixic acid-susceptible and -resistant isolates of Shigella dysenteriae type 1 was amplified by PCR, cloned, and sequenced. DNA sequence analysis of gyrA from nalidixic acid-resistant isolates revealed a C-to-T transition at nucleotide position 248 leading to a Ser-83-to-Leu substitution which was absent in susceptible clinical isolates. Direct HinfI digestion of PCR-amplified DNA detected similar mutations. Thus, DNA gyrase A subunit mutation Ser-83 to Leu is implicated in 4-quinolone resistance in S. dysenteriae type 1. | lld:pubmed |
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| pubmed-article:7840594 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7840594 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7840594 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7840594 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7840594 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7840594 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:7840594 | pubmed:author | pubmed-author:PulvererGG | lld:pubmed |
| pubmed-article:7840594 | pubmed:author | pubmed-author:RahmanMM | lld:pubmed |
| pubmed-article:7840594 | pubmed:author | pubmed-author:LevyJJ | lld:pubmed |
| pubmed-article:7840594 | pubmed:author | pubmed-author:ButzlerJ PJP | lld:pubmed |
| pubmed-article:7840594 | pubmed:author | pubmed-author:MauffGG | lld:pubmed |
| pubmed-article:7840594 | pubmed:author | pubmed-author:CouturierMM | lld:pubmed |
| pubmed-article:7840594 | pubmed:author | pubmed-author:GlasdorffNN | lld:pubmed |
| pubmed-article:7840594 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7840594 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:7840594 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7840594 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7840594 | pubmed:pagination | 2488-91 | lld:pubmed |
| pubmed-article:7840594 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7840594 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7840594 | pubmed:articleTitle | Detection of 4-quinolone resistance mutation in gyrA gene of Shigella dysenteriae type 1 by PCR. | lld:pubmed |
| pubmed-article:7840594 | pubmed:affiliation | International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka. | lld:pubmed |
| pubmed-article:7840594 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7840594 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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