| pubmed-article:7838376 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7838376 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:7838376 | lifeskim:mentions | umls-concept:C2700455 | lld:lifeskim |
| pubmed-article:7838376 | lifeskim:mentions | umls-concept:C1704708 | lld:lifeskim |
| pubmed-article:7838376 | lifeskim:mentions | umls-concept:C1158884 | lld:lifeskim |
| pubmed-article:7838376 | lifeskim:mentions | umls-concept:C1947974 | lld:lifeskim |
| pubmed-article:7838376 | lifeskim:mentions | umls-concept:C1720655 | lld:lifeskim |
| pubmed-article:7838376 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7838376 | pubmed:dateCreated | 1995-3-2 | lld:pubmed |
| pubmed-article:7838376 | pubmed:abstractText | Microtubule-associated protein tau is abnormally hyperphosphorylated in the brain of patients with Alzheimer's disease, and is the major protein subunit of paired helical filaments. There is also a significant pool of non-paired helical filament abnormally phosphorylated tau in Alzheimer's disease brain. In the present study, the site-specific dephosphorylation of this Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A was studied and compared with that by protein phosphatase-2B. The dephosphorylation was detected by its interaction with several phosphorylation-dependent antibodies to various abnormal phosphorylation sites. Protein phosphatase-2A was able to dephosphorylate the abnormally phosphorylated tau at Ser-46, Ser-199, Ser-202, Ser-396 and Ser-404, but not at Ser-235 (the amino acids are numbered according to the largest isoform of human tau, tau441). Two major types of protein phosphatase-2A, protein phosphatase-2A1 and -2A2, dephosphorylated the abnormally phosphorylated tau at approximately the same rate. After the abnormally phosphorylated tau was dephosphorylated by protein phosphatase-2A, its relative mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis increased. The dephosphorylation of the abnormal tau by protein phosphatase-2A1 and -2A2 was markedly stimulated by Mn2+. These results suggest that tau dephosphorylation is catalysed by protein phosphatase-2A in addition to protein phosphatase-2B. A deficiency of either protein phosphatase-2A or -2B, or both, may be involved in abnormal phosphorylation of tau in Alzheimer's disease. | lld:pubmed |
| pubmed-article:7838376 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7838376 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7838376 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7838376 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7838376 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7838376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7838376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7838376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7838376 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7838376 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7838376 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:7838376 | pubmed:author | pubmed-author:IqbalKK | lld:pubmed |
| pubmed-article:7838376 | pubmed:author | pubmed-author:Grundke-Iqbal... | lld:pubmed |
| pubmed-article:7838376 | pubmed:author | pubmed-author:DUDAS ASA | lld:pubmed |
| pubmed-article:7838376 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7838376 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:7838376 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7838376 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7838376 | pubmed:pagination | 765-72 | lld:pubmed |
| pubmed-article:7838376 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7838376 | pubmed:meshHeading | pubmed-meshheading:7838376-... | lld:pubmed |
| pubmed-article:7838376 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7838376 | pubmed:articleTitle | Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A. | lld:pubmed |
| pubmed-article:7838376 | pubmed:affiliation | New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314. | lld:pubmed |
| pubmed-article:7838376 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7838376 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7838376 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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