| pubmed-article:7836208 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C0035245 | lld:lifeskim |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C0003601 | lld:lifeskim |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C0032740 | lld:lifeskim |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C0038891 | lld:lifeskim |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C1550605 | lld:lifeskim |
| pubmed-article:7836208 | lifeskim:mentions | umls-concept:C0456205 | lld:lifeskim |
| pubmed-article:7836208 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7836208 | pubmed:dateCreated | 1995-2-24 | lld:pubmed |
| pubmed-article:7836208 | pubmed:abstractText | To study the in vivo activity of the surfactant apoproteins (SP-A, SP-B, SP-C), we administered surfactants with defined apoprotein compositions to prematurely delivered rabbit pups. Rabbits given simple phospholipid mixtures containing dipalmitoylphosphatidylcholine and phosphatidylglycerol supplemented with both SP-B and SP-C or either protein alone had significantly greater lung compliance during ventilation and lung expansion during a quasi-static pressure-volume maneuver than did saline-or lipid-treated controls. The response to the surfactants containing SP-B/C was markedly dependent on the level of end-expiratory pressure used during ventilation. When the rabbits were ventilated with a positive end-expiratory pressure (PEEP) of 4 cmH2O, lung function in the pups treated with SP-B/C was not significantly different from rabbit surfactant-treated controls. Addition of SP-A to the surfactants containing SP-B/C did not significantly further improve lung function if the pups were ventilated with a PEEP of 4 cmH2O. With a lower PEEP of 1 cmH2O, lung function in the pups given surfactants containing SP-B/C was no longer equivalent to the lung function of the rabbit surfactant-treated controls. At the lower PEEP, SP-A significantly improved lung function when it was added to surfactants containing SP-B and SP-C. No beneficial effect of SP-A was seen when the surfactant contained either SP-B or SP-C alone. We conclude that with assisted ventilation that includes a moderate level of PEEP, SP-B and SP-C significantly enhance the effect of a simple phospholipid mixture on the lung function of prematurely delivered rabbits. At lower levels of PEEP the effects of SP-B and SP-C on lung function are markedly reduced but can be restored by the addition of SP-A. Our results are consistent with the existence of cooperative protein-protein interactions in surfactant function in vivo and suggest that the response to a surfactant will be determined by both the ventilation strategy and the surfactant composition. composition. | lld:pubmed |
| pubmed-article:7836208 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836208 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7836208 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836208 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7836208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836208 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7836208 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7836208 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7836208 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:7836208 | pubmed:author | pubmed-author:ClementsJ AJA | lld:pubmed |
| pubmed-article:7836208 | pubmed:author | pubmed-author:SchlueterM... | lld:pubmed |
| pubmed-article:7836208 | pubmed:author | pubmed-author:BrownC LCL | lld:pubmed |
| pubmed-article:7836208 | pubmed:author | pubmed-author:OgawaAA | lld:pubmed |
| pubmed-article:7836208 | pubmed:author | pubmed-author:BensonB JBJ | lld:pubmed |
| pubmed-article:7836208 | pubmed:author | pubmed-author:HawgoodSS | lld:pubmed |
| pubmed-article:7836208 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7836208 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:7836208 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7836208 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7836208 | pubmed:pagination | 1840-9 | lld:pubmed |
| pubmed-article:7836208 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:meshHeading | pubmed-meshheading:7836208-... | lld:pubmed |
| pubmed-article:7836208 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7836208 | pubmed:articleTitle | Lung function, surfactant apoprotein content, and level of PEEP in prematurely delivered rabbits. | lld:pubmed |
| pubmed-article:7836208 | pubmed:affiliation | Cardiovascular Research Institute, University of California, San Francisco 94143. | lld:pubmed |
| pubmed-article:7836208 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7836208 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7836208 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7836208 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
