| pubmed-article:7835425 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C1704319 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C0001044 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:7835425 | lifeskim:mentions | umls-concept:C0456148 | lld:lifeskim |
| pubmed-article:7835425 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7835425 | pubmed:dateCreated | 1995-2-24 | lld:pubmed |
| pubmed-article:7835425 | pubmed:abstractText | Two genes (ace-1 and ace-2) encode two major classes (A and B) of acetylcholinesterase (AChE) in the nematode Caenorhabditis elegans. A null mutation in ace-1 (allele p1000) suppresses all acetylcholinesterase activity of class A. We have identified an opal mutation TGG (W99)-->TGA (Stop) as the only alteration in the mutated gene. This leads to a truncated protein (98 instead of 620 amino acids) with no enzymatic activity. The mutation also reduces the level of ace-1 transcripts to only 10% of that in wild-type animals. This most likely results from a destabilization of mRNA containing the nonsense message. In contrast, compensation of class B by class A AChE in the null mutant strain ace-2 takes place with unchanged ace-1 mRNA level and enzymatic activity similar to class A AChE. | lld:pubmed |
| pubmed-article:7835425 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7835425 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835425 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7835425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7835425 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7835425 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7835425 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:7835425 | pubmed:author | pubmed-author:ToutantJ PJP | lld:pubmed |
| pubmed-article:7835425 | pubmed:author | pubmed-author:ArpagausMM | lld:pubmed |
| pubmed-article:7835425 | pubmed:author | pubmed-author:BernardiHH | lld:pubmed |
| pubmed-article:7835425 | pubmed:author | pubmed-author:TannerS ESE | lld:pubmed |
| pubmed-article:7835425 | pubmed:author | pubmed-author:FedonYY | lld:pubmed |
| pubmed-article:7835425 | pubmed:author | pubmed-author:CulettoEE | lld:pubmed |
| pubmed-article:7835425 | pubmed:author | pubmed-author:SchirruNN | lld:pubmed |
| pubmed-article:7835425 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7835425 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:7835425 | pubmed:volume | 357 | lld:pubmed |
| pubmed-article:7835425 | pubmed:geneSymbol | ace-2 | lld:pubmed |
| pubmed-article:7835425 | pubmed:geneSymbol | ace-1 | lld:pubmed |
| pubmed-article:7835425 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7835425 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7835425 | pubmed:pagination | 265-8 | lld:pubmed |
| pubmed-article:7835425 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:meshHeading | pubmed-meshheading:7835425-... | lld:pubmed |
| pubmed-article:7835425 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7835425 | pubmed:articleTitle | Characterization of a null mutation in ace-1, the gene encoding class A acetylcholinesterase in the nematode Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:7835425 | pubmed:affiliation | Différenciation cellulaire et Croissance, Physiologie animale INRA, Montpellier, France. | lld:pubmed |
| pubmed-article:7835425 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7835425 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:181706 | entrezgene:pubmed | pubmed-article:7835425 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7835425 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7835425 | lld:pubmed |
