| pubmed-article:7833367 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C0017296 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7833367 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:7833367 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7833367 | pubmed:dateCreated | 1995-2-24 | lld:pubmed |
| pubmed-article:7833367 | pubmed:abstractText | We have constructed recombinant human adenoviruses that express wild-type human p53 under the control of either the Ad 2 major late promoter (MLP) or the human cytomegalovirus (CMV) immediate early gene promoter. Each construct replaces the Ad 5 E1a and E1b coding sequences necessary for viral replication with the p53 cDNA and MLP or CMV promoter. These p53/Ad recombinants are able to express p53 protein in a dose-dependent manner in infected human cancer cells. Tumor suppressor activity of the expressed p53 protein was assayed by several methods. [3H]Thymidine incorporation assays showed that the recombinant adenoviruses were capable of inhibiting DNA synthesis in a p53-specific, dose-dependent fashion. Ex vivo treatment of Saos-2 tumor cells, followed by injection of the treated cells into nude mice, led to complete tumor suppression using the MLP/p53 recombinant. Following a single injection of CMV/p53 recombinant adenovirus into the peritumoral space surrounding an in vivo established tumor derived from a human small cell lung carcinoma cell line (NIH-H69), we were able to detect p53 mRNA in the tumors at 2 and 7 days post-injection. Continued treatment of established H69 tumors with MLP/p53 recombinant led to reduced tumor growth and increased survival time compared to control treated animals. These results indicate that recombinant adenoviruses expressing wild-type p53 may be useful vectors for gene therapy of human cancer. | lld:pubmed |
| pubmed-article:7833367 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7833367 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7833367 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7833367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7833367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7833367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7833367 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7833367 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7833367 | pubmed:issn | 1043-0342 | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:JohnsonD EDE | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:HuangW MWM | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:RaoN KNK | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:AndersonS CSC | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:SutjiptoSS | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:WillsK NKN | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:MenzelPP | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:ManevalD CDC | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:HarrisM PMP | lld:pubmed |
| pubmed-article:7833367 | pubmed:author | pubmed-author:VaillancourtM... | lld:pubmed |
| pubmed-article:7833367 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7833367 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:7833367 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7833367 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7833367 | pubmed:pagination | 1079-88 | lld:pubmed |
| pubmed-article:7833367 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7833367 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7833367 | pubmed:articleTitle | Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. | lld:pubmed |
| pubmed-article:7833367 | pubmed:affiliation | CANJI, Inc., San Diego, CA 92121. | lld:pubmed |
| pubmed-article:7833367 | pubmed:publicationType | Journal Article | lld:pubmed |
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