A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

Source:http://linkedlifedata.com/resource/pubmed/id/7829529

J. Biol. Chem. 1995 Jan 27 270 4 1913-20

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PMID
7829529