| pubmed-article:7823615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C0005367 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C0007012 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C0007026 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C0025973 | lld:lifeskim |
| pubmed-article:7823615 | lifeskim:mentions | umls-concept:C1519355 | lld:lifeskim |
| pubmed-article:7823615 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7823615 | pubmed:dateCreated | 1995-2-16 | lld:pubmed |
| pubmed-article:7823615 | pubmed:abstractText | The extracellular pH of the brain is subject to shifts during neural activity. To understand these pH changes, it is necessary to measure [H+], [HCO3-], [CO3(2-)] and [CO2]. In principle, this can be accomplished using CO3(2-) and pH-sensitive microelectrodes; however, interference from HCO3- and Cl-, and physiological changes in [HCO3-], complicate measurements with CO3(2-) electrodes. Calibration requires knowledge of slope response, interference constants and corrections for [HCO3-] shifts. We show that when [HCO3-] is altered at constant [CO2] in the absence of Cl-, the HCO3- interference cancels and the Nikolsky equation reduces to the Nernst equation for CO3(2-). Measurement of CO3(2-) slope response by this method yielded a value of 28.5 +/- 0.72 mV per decade change in [CO3(2-)]. In Cl(-)-containing solutions, interference coefficient for HCO3- and Cl- were determined by altering [HCO3-] at constant [CO2], changing [CO2] at constant [HCO3-], then solving the simultaneous Nikolsky equations for each transition. The mean interference constants corresponded to selectivity ratios of 245:1 and 1150:1 for CO3(2-) over HCO3- and Cl- respectively. To correct for possible changes in [HCO3-], the equilibrium relation between CO3(2-) and HCO3- was substituted into the Nikolsky equation to yield an equation in [CO3(2-)] and [H+]. By simultaneously measuring shifts in [H+] with a pH microelectrode, this equation is readily solved for [CO3(2-)]. These methods were tested by measuring [HCO3-] and [CO2] in experimental solutions, and in the extracellular fluid of rat hippocampal slices. | lld:pubmed |
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| pubmed-article:7823615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7823615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7823615 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7823615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7823615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7823615 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7823615 | pubmed:issn | 0165-0270 | lld:pubmed |
| pubmed-article:7823615 | pubmed:author | pubmed-author:CheslerMM | lld:pubmed |
| pubmed-article:7823615 | pubmed:author | pubmed-author:ChenJ CJC | lld:pubmed |
| pubmed-article:7823615 | pubmed:author | pubmed-author:KraigR PRP | lld:pubmed |
| pubmed-article:7823615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7823615 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:7823615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7823615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7823615 | pubmed:pagination | 129-36 | lld:pubmed |
| pubmed-article:7823615 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:7823615 | pubmed:meshHeading | pubmed-meshheading:7823615-... | lld:pubmed |
| pubmed-article:7823615 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7823615 | pubmed:articleTitle | Determination of extracellular bicarbonate and carbon dioxide concentrations in brain slices using carbonate and pH-selective microelectrodes. | lld:pubmed |
| pubmed-article:7823615 | pubmed:affiliation | Department of Physiology, New York University Medical Center, NY 10016. | lld:pubmed |
| pubmed-article:7823615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7823615 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7823615 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7823615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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