| pubmed-article:7817932 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7817932 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:7817932 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:7817932 | lifeskim:mentions | umls-concept:C0018802 | lld:lifeskim |
| pubmed-article:7817932 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:7817932 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:7817932 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:7817932 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7817932 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7817932 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7817932 | pubmed:dateCreated | 1995-2-9 | lld:pubmed |
| pubmed-article:7817932 | pubmed:abstractText | Congestive heart failure is associated with chronotropic and inotropic hyporesponsiveness to adrenergic stimulation. A decrease in Gs alpha or an increase in Gi alpha is associated with a decrease in adenylyl cyclase activity. The current study assessed G proteins in response to treatment with direct-acting vasodilators and correlated changes in lymphocyte beta-adrenergic receptor components with changes in hemodynamic variables. Twenty-three patients with severe chronic congestive heart failure (New York Heart Association functional classes III and IV) were studied. Patients were grouped as responders (n = 10) or nonresponders (n = 13) on the basis of clinical assessment of functional status from questionnaires. Therapy was associated with an increase in cardiac index, a decrease in mean arterial pressure, and a decrease in systemic vascular resistance in all patients. Left ventricular filling pressure significantly decreased in responders (26 +/- 2 mm to 13 +/- 3 mm, p < 0.05) but did not change significantly in nonresponders. Similarly, mean right atrial pressure significantly decreased in responders (11 +/- 2 mm Hg to 4 +/- 1 mm Hg, p < 0.05) but did not change in nonresponders. Plasma norepinephrine increased significantly only in nonresponders (679 +/- 100 pg/ml to 1233 +/- 201 pg/ml, p < 0.05). Whereas lymphocyte beta-adrenergic receptor density and Gs did not significantly change, Gi increased after treatment only in the nonresponder group (23 +/- 5 to 51 +/- 11 fmol/mg, p < 0.05). A poor response to direct-acting vasodilators can be distinguished by reactive increases in plasma norepinephrine and lymphocyte Gi in the absence of a decrease in either left- or right-sided filling pressures. | lld:pubmed |
| pubmed-article:7817932 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7817932 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7817932 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7817932 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7817932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7817932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7817932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7817932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7817932 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7817932 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7817932 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7817932 | pubmed:issn | 0002-8703 | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:BilezikianJ... | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:McCartyMM | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:PackerMM | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:MedinaNN | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:GratchMM | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:GoldsmithR... | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:KukinM LML | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:HornE MEM | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:YushakMM | lld:pubmed |
| pubmed-article:7817932 | pubmed:author | pubmed-author:NeubergG WGW | lld:pubmed |
| pubmed-article:7817932 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7817932 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:7817932 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7817932 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7817932 | pubmed:pagination | 98-106 | lld:pubmed |
| pubmed-article:7817932 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:meshHeading | pubmed-meshheading:7817932-... | lld:pubmed |
| pubmed-article:7817932 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7817932 | pubmed:articleTitle | Lymphocyte G proteins reflect response to treatment in congestive heart failure. | lld:pubmed |
| pubmed-article:7817932 | pubmed:affiliation | Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, N.Y. | lld:pubmed |
| pubmed-article:7817932 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7817932 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7817932 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7817932 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
