| pubmed-article:7815190 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7815190 | lifeskim:mentions | umls-concept:C1721094 | lld:lifeskim |
| pubmed-article:7815190 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:7815190 | lifeskim:mentions | umls-concept:C0021717 | lld:lifeskim |
| pubmed-article:7815190 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:7815190 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7815190 | lifeskim:mentions | umls-concept:C1518422 | lld:lifeskim |
| pubmed-article:7815190 | lifeskim:mentions | umls-concept:C1450073 | lld:lifeskim |
| pubmed-article:7815190 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7815190 | pubmed:dateCreated | 1995-2-8 | lld:pubmed |
| pubmed-article:7815190 | pubmed:abstractText | The influence of the nature of ligands on the efficiency of ruthenium complexes for photosensitizing DNA cleavage was investigated. Ru(bipy)2dppz2+ and Ru(bpz)2dppz2+ were selected as DNA breakers on the basis of their high affinity for DNA due to the presence of a dppz ligand which can partially intercalate in the major groove of DNA. Their photosensitizing properties were compared to those of Ru(bipy)3(2+), a complex which binds to DNA with a far lower constant. Upon irradiation, these complexes promoted the formation of single strand breaks in supercoiled phi X 174 DNA. Unexpectedly, Ru(bipy)2dppz2+ was found to be less efficient than Ru(bipy)3(2+) whatever the dye concentration or the [base pair]/[Ru] molar ratio r. Scavenging experiments have shown that the oxidative DNA cleavage induced by Ru(bipy)2dppz2+ mainly results from a Type II mechanism. The behavior of Ru(bipy)2dppz2+ was different: this compound was clearly more efficient than Ru(bipy)3(2+) as DNA breaker and its efficiency was not modified by the presence of oxygen or by addition of scavengers of reactive oxygen species. In this case, a mechanism involving electron transfer between the excited state of the ruthenium complex and the guanine residue was proposed in agreement emission lifetime measurements. The change in mechanism observed between Ru(bipy)2dppz2+ and Ru (bipy)2dppz2+ results from an increase of the reduction potential of the ruthenium complexes in the excited state, which appears to be the main factor controlling the efficiency. | lld:pubmed |
| pubmed-article:7815190 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7815190 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815190 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7815190 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7815190 | pubmed:issn | 1011-1344 | lld:pubmed |
| pubmed-article:7815190 | pubmed:author | pubmed-author:SauvageJ PJP | lld:pubmed |
| pubmed-article:7815190 | pubmed:author | pubmed-author:PaillousNN | lld:pubmed |
| pubmed-article:7815190 | pubmed:author | pubmed-author:SentagneCC | lld:pubmed |
| pubmed-article:7815190 | pubmed:author | pubmed-author:ChambronJ CJC | lld:pubmed |
| pubmed-article:7815190 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7815190 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:7815190 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7815190 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7815190 | pubmed:pagination | 165-74 | lld:pubmed |
| pubmed-article:7815190 | pubmed:dateRevised | 2007-7-23 | lld:pubmed |
| pubmed-article:7815190 | pubmed:meshHeading | pubmed-meshheading:7815190-... | lld:pubmed |
| pubmed-article:7815190 | pubmed:meshHeading | pubmed-meshheading:7815190-... | lld:pubmed |
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| pubmed-article:7815190 | pubmed:meshHeading | pubmed-meshheading:7815190-... | lld:pubmed |
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| pubmed-article:7815190 | pubmed:meshHeading | pubmed-meshheading:7815190-... | lld:pubmed |
| pubmed-article:7815190 | pubmed:meshHeading | pubmed-meshheading:7815190-... | lld:pubmed |
| pubmed-article:7815190 | pubmed:meshHeading | pubmed-meshheading:7815190-... | lld:pubmed |
| pubmed-article:7815190 | pubmed:meshHeading | pubmed-meshheading:7815190-... | lld:pubmed |
| pubmed-article:7815190 | pubmed:meshHeading | pubmed-meshheading:7815190-... | lld:pubmed |
| pubmed-article:7815190 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7815190 | pubmed:articleTitle | Tuning the mechanism of DNA cleavage photosensitized by ruthenium dipyridophenazine complexes by varying the structure of the two non intercalating ligands. | lld:pubmed |
| pubmed-article:7815190 | pubmed:affiliation | Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, Université Paul Sabatier, Toulouse Cedex, France. | lld:pubmed |
| pubmed-article:7815190 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7815190 | pubmed:publicationType | Comparative Study | lld:pubmed |
