| pubmed-article:7814643 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7814643 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7814643 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7814643 | lifeskim:mentions | umls-concept:C0061355 | lld:lifeskim |
| pubmed-article:7814643 | lifeskim:mentions | umls-concept:C1562292 | lld:lifeskim |
| pubmed-article:7814643 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:7814643 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7814643 | pubmed:dateCreated | 1995-2-9 | lld:pubmed |
| pubmed-article:7814643 | pubmed:abstractText | Glucagon-like peptide-1 7-36 amide (GLP-1) has been postulated to be the primary hormonal mediator of the entero-insular axis but evidence has been indirect. The discovery of exendin (9-39), a GLP-1 receptor antagonist, allowed this to be further investigated. The IC50 for GLP-1 receptor binding, using RIN 5AH beta-cell membranes, was found to be 0.36 nmol/l for GLP-1 and 3.44 nmol/l for exendin (9-39). There was no competition by exendin (9-39) at binding sites for glucagon or related peptides. In the anaesthetized fasted rat, insulin release after four doses of GLP-1 (0.1, 0.2, 0.3, and 0.4 nmol/kg) was tested by a 2-min intravenous infusion. Exendin (9-39) (1.5, 3.0, and 4.5 nmol/kg) was administered with GLP-1 0.3 nmol/kg, or saline, and only the highest dose fully inhibited insulin release. Exendin (9-39) at 4.5 nmol/kg had no effect on glucose, arginine, vasoactive intestinal peptide or glucose-dependent insulinotropic peptide stimulated insulin secretion. Postprandial insulin release was studied in conditioned conscious rats after a standard meal. Exendin (9-39) (0.5 nmol/kg) considerably reduced postprandial insulin concentrations, for example by 48% at 15 min (431 +/- 21 pmol/l saline, 224 +/- 32 pmol/l exendin, P < 0.001). Thus, GLP-1 appears to play a major role in the entero-insular axis. | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7814643 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7814643 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7814643 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7814643 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:7814643 | pubmed:author | pubmed-author:BloomS RSR | lld:pubmed |
| pubmed-article:7814643 | pubmed:author | pubmed-author:SmithD MDM | lld:pubmed |
| pubmed-article:7814643 | pubmed:author | pubmed-author:WangR MRM | lld:pubmed |
| pubmed-article:7814643 | pubmed:author | pubmed-author:GhateiM AMA | lld:pubmed |
| pubmed-article:7814643 | pubmed:author | pubmed-author:WangZZ | lld:pubmed |
| pubmed-article:7814643 | pubmed:author | pubmed-author:OwjiA AAA | lld:pubmed |
| pubmed-article:7814643 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7814643 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:7814643 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7814643 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7814643 | pubmed:pagination | 417-21 | lld:pubmed |
| pubmed-article:7814643 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:meshHeading | pubmed-meshheading:7814643-... | lld:pubmed |
| pubmed-article:7814643 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7814643 | pubmed:articleTitle | Glucagon-like peptide-1 is a physiological incretin in rat. | lld:pubmed |
| pubmed-article:7814643 | pubmed:affiliation | Division of Endocrinology, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom. | lld:pubmed |
| pubmed-article:7814643 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7814643 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7814643 | lld:pubmed |
