| pubmed-article:7813807 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C0919453 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C0008669 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C1710961 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C1415690 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:7813807 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:7813807 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7813807 | pubmed:dateCreated | 1995-2-7 | lld:pubmed |
| pubmed-article:7813807 | pubmed:abstractText | Type I diabetes susceptibility genes have been identified within the major histocompatibility complex (MHC) on chromosome 6p21.3 and near the VNTR/insulin region on chromosome 11p15.5. We have used polymorphic dinucleotide repeat markers to search the human genome for additional susceptibility genes in 162 type I diabetic families with an affected sibling pair. We report that an additional susceptibility gene is located on chromosome 2q31 near HOXD8 (P < 10(-5), maximum logarithm of odds score = 4.8) in an analysis of affected sibling pairs having specific human leukocyte antigen (HLA) and hypervariable nucleotide tandem repeat (VNTR)/insulin gene haplotypes (absence of high-risk HLA-DR3/4 haplotypes and presence of homozygous high-risk class I VNTR alleles). These results suggest the interaction of a minimum of three genes in the pathogenesis of type I diabetes in humans. | lld:pubmed |
| pubmed-article:7813807 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7813807 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7813807 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7813807 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7813807 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7813807 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:7813807 | pubmed:author | pubmed-author:GabbayK HKH | lld:pubmed |
| pubmed-article:7813807 | pubmed:author | pubmed-author:OwerbachDD | lld:pubmed |
| pubmed-article:7813807 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7813807 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:7813807 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7813807 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7813807 | pubmed:pagination | 132-6 | lld:pubmed |
| pubmed-article:7813807 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:meshHeading | pubmed-meshheading:7813807-... | lld:pubmed |
| pubmed-article:7813807 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7813807 | pubmed:articleTitle | The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 6 and 11 disease susceptibility genes. | lld:pubmed |
| pubmed-article:7813807 | pubmed:affiliation | Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030. | lld:pubmed |
| pubmed-article:7813807 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7813807 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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