| pubmed-article:7812632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7812632 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:7812632 | lifeskim:mentions | umls-concept:C0018338 | lld:lifeskim |
| pubmed-article:7812632 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:7812632 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7812632 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:7812632 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:7812632 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:7812632 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7812632 | pubmed:dateCreated | 1995-2-8 | lld:pubmed |
| pubmed-article:7812632 | pubmed:abstractText | FK409 ((+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide) , which has been reported by us to be a new spontaneous nitric oxide (NO) releaser, prevented myocardial infarction following occlusion and reperfusion in rat coronary artery and increased plasma cyclic GMP level in rats, dose-dependently and significantly at 32 mg kg-1. Isosorbide dinitrate (ISDN), which is the most popular orally active NO donor used in the treatment of ischaemic cardiovascular diseases, did not show significant effects at 32 mg kg-1 in either experiment. Therefore, it is suggested that FK409 can attenuate myocardial injury during ischaemia and reperfusion in contrast to ISDN and a change in plasma cyclic GMP level may serve as an indicator of the cardioprotective effect of NO-releasing drugs. | lld:pubmed |
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| pubmed-article:7812632 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7812632 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812632 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7812632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7812632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7812632 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7812632 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7812632 | pubmed:author | pubmed-author:YoshidaKK | lld:pubmed |
| pubmed-article:7812632 | pubmed:author | pubmed-author:SugimotoTT | lld:pubmed |
| pubmed-article:7812632 | pubmed:author | pubmed-author:MaedaKK | lld:pubmed |
| pubmed-article:7812632 | pubmed:author | pubmed-author:HirasawaYY | lld:pubmed |
| pubmed-article:7812632 | pubmed:author | pubmed-author:KitaYY | lld:pubmed |
| pubmed-article:7812632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7812632 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:7812632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7812632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7812632 | pubmed:pagination | 5-6 | lld:pubmed |
| pubmed-article:7812632 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7812632 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7812632 | pubmed:articleTitle | Close correlation of the cardioprotective effect of FK409, a spontaneous NO releaser, with an increase in plasma cyclic GMP level. | lld:pubmed |
| pubmed-article:7812632 | pubmed:affiliation | Department of Pharmacology, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan. | lld:pubmed |
| pubmed-article:7812632 | pubmed:publicationType | Journal Article | lld:pubmed |
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