| pubmed-article:7812616 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0036226 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0182400 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:7812616 | lifeskim:mentions | umls-concept:C0067064 | lld:lifeskim |
| pubmed-article:7812616 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7812616 | pubmed:dateCreated | 1995-2-8 | lld:pubmed |
| pubmed-article:7812616 | pubmed:abstractText | 1. Myotoxin alpha (MYTX), a polypeptide toxin purified from the venom of prairie rattlesnakes (Crotalus viridis viridis) induced Ca2+ release from the heavy fraction (HSR) but not the light fraction of skeletal sarcoplasmic reticulum at concentrations higher than 1 microM, followed by spontaneous Ca2+ reuptake by measuring extravesicular Ca2+ concentrations using the Ca2+ electrode. 2. The rate of 45Ca2+ release from HSR vesicles was markedly accelerated by MYTX in a concentration-dependent manner in the range of concentrations between 30 nM and 10 microM, indicating the most potent Ca2+ releaser in HSR. 3. The Ca2+ dependency of MYTX-induced 45Ca2+ release has a bell-shaped profile but it was quite different from that of caffeine, an inducer of Ca(2+)-induced Ca2+ release. 4. 45Ca2+ release induced by MYTX was remarkable in the range of pCa between 8 and 3, whereas that by caffeine was prominent in the range of pCa, i.e., between 7 and 5.5. 5. MYTX-induced 45Ca2+ release consists of both early and late components. The early component caused by MYTX at low concentrations (30-300 nM) completed within 20 s, while the late component induced by it at higher concentrations (> 0.3 microM) was maintained for at least 1 min. 6. Both the components were almost completely inhibited by inhibitors of Ca2+ such as Mg2+, ruthenium red and spermine. 7. 45Ca2+ release induced by caffeine or beta,gamma-methyleneadenosine 5'-triphosphate (AMP-PCP) was completely inhibited by high concentrations of procaine. Procaine abolished the early component but not the late one, suggesting that at least the early component is mediated through Ca(2+)-induced Ca2+ release channels. 8. On the basis of these results, the character of Ca2+ release induced by MYTX was quite different from that caused by caffeine or AMP-PCP, suggesting that MYTX induces Ca2+ release having novel properties in HSR. MYTX is the first polypeptide Ca2+ inducer and has become a useful pharmacological tool for clarifying the mechanism of Ca2+ release from skeletal muscle SR. | lld:pubmed |
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| pubmed-article:7812616 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7812616 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7812616 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7812616 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7812616 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7812616 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7812616 | pubmed:author | pubmed-author:TuA TAT | lld:pubmed |
| pubmed-article:7812616 | pubmed:author | pubmed-author:OshimaYY | lld:pubmed |
| pubmed-article:7812616 | pubmed:author | pubmed-author:FurukawaKK | lld:pubmed |
| pubmed-article:7812616 | pubmed:author | pubmed-author:OhizumiYY | lld:pubmed |
| pubmed-article:7812616 | pubmed:author | pubmed-author:OhkuraMM | lld:pubmed |
| pubmed-article:7812616 | pubmed:author | pubmed-author:FunayamaKK | lld:pubmed |
| pubmed-article:7812616 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7812616 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:7812616 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7812616 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7812616 | pubmed:pagination | 233-9 | lld:pubmed |
| pubmed-article:7812616 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7812616 | pubmed:meshHeading | pubmed-meshheading:7812616-... | lld:pubmed |
| pubmed-article:7812616 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7812616 | pubmed:articleTitle | Ca2+ release induced by myotoxin alpha, a radio-labellable probe having novel Ca2+ release properties in sarcoplasmic reticulum. | lld:pubmed |
| pubmed-article:7812616 | pubmed:affiliation | Department of Pharmaceutical Molecular Biology, Pharmaceutical Institute Tohoku University, Sendai, Japan. | lld:pubmed |
| pubmed-article:7812616 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7812616 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7812616 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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