| pubmed-article:7810664 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7810664 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7810664 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7810664 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:7810664 | lifeskim:mentions | umls-concept:C1704242 | lld:lifeskim |
| pubmed-article:7810664 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:7810664 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:7810664 | lifeskim:mentions | umls-concept:C1325893 | lld:lifeskim |
| pubmed-article:7810664 | pubmed:issue | 6 Pt 1 | lld:pubmed |
| pubmed-article:7810664 | pubmed:dateCreated | 1995-1-31 | lld:pubmed |
| pubmed-article:7810664 | pubmed:abstractText | Interleukin-1 beta (IL-1 beta) is the most potent inhibitor of gastric acid secretion known at present. Although histamine has been shown to be an important mediator of gastric acid secretion, the effect of IL-1 beta on gastric histamine mobilization has not been studied. In the present study, the effects of IL-1 beta on gastric acid secretion and gastric histamine mobilization were investigated in conscious rats with both gastric and vesical fistulas. IL-1 beta (5 micrograms/kg iv) significantly inhibited basal acid secretion but did not affect basal urinary histamine excretion and fundic histidine decarboxylase (HDC) activity. Gastrin-17-I (1 nmol.kg-1.h-1) caused a marked increase in acid secretion, urinary histamine secretion, and fundic HDC activity. IL-1 beta (5 micrograms/kg iv) completely inhibited gastrin-induced acid secretion and partially inhibited urinary histamine excretion and fundic HDC activity. Pretreatment with indomethacin (10 mg/kg ip) partially reversed the inhibitory effects of IL-1 beta on gastrin-stimulated fundic HDC activity and acid secretion. These findings indicate that IL-1 beta inhibits gastric histamine mobilization through both prostaglandin-dependent and prostaglandin-independent pathways. Furthermore, it is suggested that the inhibitory action of IL-1 beta on gastric acid secretion is mediated by the inhibition of gastric histamine mobilization. | lld:pubmed |
| pubmed-article:7810664 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7810664 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7810664 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7810664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7810664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7810664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7810664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7810664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7810664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7810664 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7810664 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7810664 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:7810664 | pubmed:author | pubmed-author:MatsuzawaYY | lld:pubmed |
| pubmed-article:7810664 | pubmed:author | pubmed-author:FukuiHH | lld:pubmed |
| pubmed-article:7810664 | pubmed:author | pubmed-author:KondoSS | lld:pubmed |
| pubmed-article:7810664 | pubmed:author | pubmed-author:MiyazakiYY | lld:pubmed |
| pubmed-article:7810664 | pubmed:author | pubmed-author:KanayamaSS | lld:pubmed |
| pubmed-article:7810664 | pubmed:author | pubmed-author:KawabataSS | lld:pubmed |
| pubmed-article:7810664 | pubmed:author | pubmed-author:ImamuraII | lld:pubmed |
| pubmed-article:7810664 | pubmed:author | pubmed-author:ShinomuraYY | lld:pubmed |
| pubmed-article:7810664 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7810664 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:7810664 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7810664 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7810664 | pubmed:pagination | G966-71 | lld:pubmed |
| pubmed-article:7810664 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:meshHeading | pubmed-meshheading:7810664-... | lld:pubmed |
| pubmed-article:7810664 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7810664 | pubmed:articleTitle | Interleukin-1 beta inhibits gastric histamine secretion and synthesis in the rat. | lld:pubmed |
| pubmed-article:7810664 | pubmed:affiliation | Second Department of Internal Medicine, Osaka University Medical School, Suita, Japan. | lld:pubmed |
| pubmed-article:7810664 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7810664 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7810664 | lld:pubmed |
