| Subject | Predicate | Object | Context |
|---|---|---|---|
| pubmed-article:780227 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:780227 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:780227 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:780227 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:780227 | lifeskim:mentions | umls-concept:C1552617 | lld:lifeskim |
| pubmed-article:780227 | lifeskim:mentions | umls-concept:C0282443 | lld:lifeskim |
| pubmed-article:780227 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:780227 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:780227 | pubmed:dateCreated | 1976-10-2 | lld:pubmed |
| pubmed-article:780227 | pubmed:abstractText | Investigation of the cell S--Ig in acute lymphocytic leukaemia (ALL), at the onset of relapse of the disease, shows quite marked differences from patient to patient according to the extent of the immunofluorescent-positive cells. They may vary from 0.5 to 25% or more. When these Ig-positive cells are treated with trypsin and then incubated "in vitro" for six hours, many of them are no longer Ig-positive, i.e. they do not synthesize Ig. It might be possible, that the membrane-Ig observed before trypsinization does not represent true Ig-determinants of mature B-cells (antibodies attached to leukaemia-specific determinants?). The extent of these features decrease in remission until their disappearance. Relationship between the cell immunological patterns and the treatment response in ALL could exist. In a group of ALL-patients under the same treatment, that is, vincristine and prednisone, the correlation between the course of the disease after the above-mentioned therapy showed quick and complete remission in patients with low percentage of Ig-positive cells (below 10%) and poor improvement (often without complete remission) in patients with higher percentage of Ig-positive cells. Among the most important B-lymphocyte abnormalities in chronic lymphocytic leukaemia (CLL) are the following: (a) fluorescence intensity may vary not only from patient to patient, but also from cell to cell in the same patient; (b) the Fc-receptor can be lacking; (c) the C3b-receptor is not always present, or it is from 2 to 20-folds less frequent than the C3d-receptor, whereas normal human lymphocytes do not show any outstanding differences between the number of EAC rosette-forming cells either when tested with mouse complement (C3d-receptor) or with human complement C3b-receptor); (d) the traffic capacity of peripheral-blood B-lymphocytes in CLL is quite defective. Results of the observations on lymphocytes in CLL, taken as a whole, suggest that CLL is in general given by the expansion of an abnormal clone of cells of B origin, arrested in their maturative development, non-responsive to the mitogen stimulation, accumulating in the peripheral-blood for a traffic deficiency. On the contrary, the T-cells class is apparently normal, and the T-cell extent in CLL-peripheral blood can be even greater than normal when taken as absolute value. | lld:pubmed |
| pubmed-article:780227 | pubmed:language | eng | lld:pubmed |
| pubmed-article:780227 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:780227 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:780227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:780227 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:780227 | pubmed:issn | 0017-6559 | lld:pubmed |
| pubmed-article:780227 | pubmed:author | pubmed-author:TopuzUU | lld:pubmed |
| pubmed-article:780227 | pubmed:author | pubmed-author:AstaldiG CGC | lld:pubmed |
| pubmed-article:780227 | pubmed:author | pubmed-author:GuarinaLL | lld:pubmed |
| pubmed-article:780227 | pubmed:author | pubmed-author:AtsaldiGG | lld:pubmed |
| pubmed-article:780227 | pubmed:issnType | lld:pubmed | |
| pubmed-article:780227 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:780227 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:780227 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:780227 | pubmed:pagination | 21-33 | lld:pubmed |
| pubmed-article:780227 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-H... | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-X... | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-S... | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-L... | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-L... | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-R... | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-T... | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-B... | lld:pubmed |
| pubmed-article:780227 | pubmed:meshHeading | pubmed-meshheading:780227-R... | lld:pubmed |
| pubmed-article:780227 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:780227 | pubmed:articleTitle | Lymphocyte immunological patterns in leukaemia: a review. | lld:pubmed |
| pubmed-article:780227 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:780227 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:780227 | lld:pubmed |