| pubmed-article:7796873 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7796873 | lifeskim:mentions | umls-concept:C2245017 | lld:lifeskim |
| pubmed-article:7796873 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:7796873 | lifeskim:mentions | umls-concept:C0085196 | lld:lifeskim |
| pubmed-article:7796873 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:7796873 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:7796873 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:7796873 | pubmed:dateCreated | 1995-7-31 | lld:pubmed |
| pubmed-article:7796873 | pubmed:abstractText | The enzymes of mitochondrial respiratory chain, NADH dehydrogenase (complex I) and cytochrome c oxidase (complex IV), were completely inhibited by 6-hydroxydopamine with IC50 = 10.5 microM and IC50 = 34 microM respectively. The enzyme inhibition was insensitive to the change of NADH or cytochrome c concentrations. The extent of complex I inhibition decreased as a consequence of both non-enzymatic and monoamine oxidase-catalyzed oxidation of 6-hydroxydopamine. Monoamine oxidase A and B inhibitors, tranylcypromine and clorgyline but not l-deprenyl increased the extent of 6-hydroxydopamine induced inhibition of complex I. Thus, 6-hydroxydopamine itself and not its oxidation products may be responsible for the neurotoxicity of this agent via inhibition of respiratory chain enzymes. | lld:pubmed |
| pubmed-article:7796873 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7796873 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796873 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7796873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7796873 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7796873 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7796873 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:7796873 | pubmed:author | pubmed-author:YoudimM BMB | lld:pubmed |
| pubmed-article:7796873 | pubmed:author | pubmed-author:GlinkaY YYY | lld:pubmed |
| pubmed-article:7796873 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7796873 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:7796873 | pubmed:volume | 292 | lld:pubmed |
| pubmed-article:7796873 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7796873 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7796873 | pubmed:pagination | 329-32 | lld:pubmed |
| pubmed-article:7796873 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7796873 | pubmed:meshHeading | pubmed-meshheading:7796873-... | lld:pubmed |
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| pubmed-article:7796873 | pubmed:meshHeading | pubmed-meshheading:7796873-... | lld:pubmed |
| pubmed-article:7796873 | pubmed:meshHeading | pubmed-meshheading:7796873-... | lld:pubmed |
| pubmed-article:7796873 | pubmed:meshHeading | pubmed-meshheading:7796873-... | lld:pubmed |
| pubmed-article:7796873 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7796873 | pubmed:articleTitle | Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine. | lld:pubmed |
| pubmed-article:7796873 | pubmed:affiliation | Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel. | lld:pubmed |
| pubmed-article:7796873 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7796873 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7796873 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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