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pubmed-article:7787140pubmed:abstractTextCytokines have been used in experimental and standard protocols for immune enhancement for cancer. The combination of interleukin-2 and interferon-alpha 2 beta has been used in experimental protocols for metastatic renal cell carcinoma. A man who developed rapidly progressive renal failure after receiving this combination therapy is reported. A renal biopsy revealed a pauci-immune crescentic glomerulonephritis. Antineutrophil cytoplasmic antibodies and antiglomerular basement membrane antibodies were absent. The spectrum of renal disease and potentially related extrarenal manifestations associated with interleukin-2 and inteferon-alpha are reviewed. A pathogenesis of altered cell-mediated immunity, consistent with abnormalities in extrarenal organs after immune enhancement, is proposed.lld:pubmed
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pubmed-article:7787140pubmed:authorpubmed-author:ParkerM GMGlld:pubmed
pubmed-article:7787140pubmed:authorpubmed-author:AtkinsM BMBlld:pubmed
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pubmed-article:7787140pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:7787140pubmed:articleTitleRapidly progressive glomerulonephritis after immunotherapy for cancer.lld:pubmed
pubmed-article:7787140pubmed:affiliationDivision of Nephrology, New England Medical Center, Boston, MA, USA.lld:pubmed
pubmed-article:7787140pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7787140pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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