| pubmed-article:7783536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7783536 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:7783536 | lifeskim:mentions | umls-concept:C0035020 | lld:lifeskim |
| pubmed-article:7783536 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:7783536 | pubmed:issue | 8965 | lld:pubmed |
| pubmed-article:7783536 | pubmed:dateCreated | 1995-7-17 | lld:pubmed |
| pubmed-article:7783536 | pubmed:abstractText | Many relapses of systemic lupus erythematosus (SLE) are preceded by a rise in antibodies against double-stranded DNA (anti-dsDNA). We investigated whether these relapses can be prevented by giving prednisone when a rise in anti-dsDNA occurs. 156 patients with SLE were studied. Anti-dsDNA was measured by Farr assay monthly. When a rise in anti-dsDNA was found, patients were randomly assigned either conventional treatment or 30 mg prednisone added to the current daily dose and tapering off to baseline over 18 weeks. A rise in anti-dsDNA was detected in 46 patients (24 assigned conventional treatment and 22 prednisolone). The relapse rate was higher in the conventional group than in the prednisolone group (20 vs 2, p < 0.001). Although rises in anti-dsDNA in the prednisone group were treated with additional prednisone, the cumulative oral doses of prednisone in the two groups did not differ significantly (p = 0.025). 7 major relapses requiring additional cytotoxic immunosuppressive treatment occurred in the conventional group versus 2 in the prednisone group. Treatment with prednisone as soon as a significant rise in anti-dsDNA occurs prevents relapse in most cases, without increasing the cumulative dose of prednisdone given. | lld:pubmed |
| pubmed-article:7783536 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7783536 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7783536 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7783536 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7783536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7783536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7783536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7783536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7783536 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7783536 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:HermannMM | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:KaterLL | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:Gmelig-Meylin... | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:KallenbergCC | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:de BoerGG | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:LimburgPP | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:BootsmaHH | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:SpronkPP | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:DerksenRR | lld:pubmed |
| pubmed-article:7783536 | pubmed:author | pubmed-author:Wolters-Dicke... | lld:pubmed |
| pubmed-article:7783536 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7783536 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:7783536 | pubmed:volume | 345 | lld:pubmed |
| pubmed-article:7783536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7783536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7783536 | pubmed:pagination | 1595-9 | lld:pubmed |
| pubmed-article:7783536 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7783536 | pubmed:meshHeading | pubmed-meshheading:7783536-... | lld:pubmed |
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| pubmed-article:7783536 | pubmed:meshHeading | pubmed-meshheading:7783536-... | lld:pubmed |
| pubmed-article:7783536 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7783536 | pubmed:articleTitle | Prevention of relapses in systemic lupus erythematosus. | lld:pubmed |
| pubmed-article:7783536 | pubmed:affiliation | Department of Internal Medicine, University Hospital Groningen, Netherlands. | lld:pubmed |
| pubmed-article:7783536 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7783536 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7783536 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:7783536 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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