Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

Source:http://linkedlifedata.com/resource/pubmed/id/7783135

J. Med. Chem. 1995 Jun 9 38 12 2041-9

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7783135